Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 6/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.40 |
| ▸ | CLK2 | P49760 | 5/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1674991 | 0.88 | CLK4 (0.47) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675212 | 0.82 | CLK4 (0.54) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675188 | 0.81 | CLK4 (0.46) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675111 | 0.80 | CLK4 (0.57) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675187 | 0.79 | CLK4 (0.39) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675291 | 0.77 | CLK4 (0.50) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675221 | 0.75 | CLK1 (0.49) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675100 | 0.73 | CLK4 (0.55) | CLK1CLK4CLK2DYRK1BALDH1A1 | |
| SCHEMBL1675232 | 0.71 | CLK4 (0.66) | CLK1CLK4CLK2DYRK1BDYRK1A | |
| SCHEMBL1675287 | 0.69 | CLK4 (0.79) | CLK1CLK4CLK2DYRK1BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | claimed |
| WO-2011041655-A1 | QUINAZOLIN-4-AMINE DERIVATIVES; AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-07 | — | — | WO | disclosed |