Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15779544 | 0.76 | KDM4E (0.44) | ALDH1A1TP53KDM4ERECQLCCR1 | |
| SCHEMBL15491625 | 0.75 | KDM4E (0.46) | ALDH1A1TP53KDM4ERECQLCCR1 | |
| SCHEMBL1119932 | 0.75 | KDM4E (0.46) | ALDH1A1TP53KDM4ERECQLCCR1 | |
| SCHEMBL15491626 | 0.75 | KDM4E (0.46) | ALDH1A1TP53KDM4ERECQLCCR1 | |
| SCHEMBL16751923 | 0.73 | ACHE (0.36) | ALDH1A1TP53MAPTCMA1CCR1 | |
| SCHEMBL13715899 | 0.71 | MAPT (0.35) | ALDH1A1TP53MAPTHTTAPAF1 | |
| SCHEMBL11828573 | 0.70 | ALDH1A1 (0.73) | ALDH1A1TP53MAPTHTTAPAF1 | |
| SCHEMBL11832908 | 0.69 | MAPT (0.37) | ALDH1A1TP53MAPTHTTAPAF1 | |
| SCHEMBL11833735 | 0.69 | ALDH1A1 (0.58) | ALDH1A1TP53MAPTHTTAPAF1 | |
| SCHEMBL16751906 | 0.69 | ACHE (0.36) | ALDH1A1HTTCMA1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3896068-A1 | S1P3 ANTAGONISTS | Teva Pharmaceutical Industries Limited (IL) | 2021-10-20 | — | — | EP | disclosed |
| EP-3689864-A1 | S1P3 ANTAGONISTS | Teva Pharmaceutical Industries Limited (IL) | 2020-08-05 | — | — | EP | disclosed |
| EP-3086845-B1 | S1P3 ANTAGONISTS | TEVA PHARMACEUTICAL INDUSTRIES LTD (IL) | 2019-11-20 | — | — | EP | disclosed |
| EP-2878339-A1 | SIP3 antagonists | Siena Biotech S.p.A. (IT) | 2015-06-03 | — | — | EP | disclosed |