Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 15/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15491625 | 1.00 | KDM4E (0.46) | KDM4ERECQLCCR1TDP1ALDH1A1 | |
| SCHEMBL15491626 | 1.00 | KDM4E (0.46) | KDM4ERECQLCCR1TDP1ALDH1A1 | |
| SCHEMBL15779544 | 0.86 | KDM4E (0.44) | KDM4ERECQLCCR1TDP1ALDH1A1 | |
| SCHEMBL1775809 | 0.81 | KDM4E (0.46) | KDM4ERECQLCCR1TDP1ALDH1A1 | |
| SCHEMBL15491628 | 0.79 | RIPK1 (0.41) | KDM4ERECQLCCR1TDP1ALDH1A1 | |
| SCHEMBL15484896 | 0.78 | KDM4E (0.44) | KDM4ERECQLCCR1TDP1NLRP3 | |
| SCHEMBL13024570 | 0.77 | CCR1 (0.45) | KDM4ERECQLCCR1TDP1ALDH1A1 | |
| SCHEMBL15492970 | 0.76 | KDM4E (0.45) | KDM4ERECQLCCR1TDP1ALDH1A1 | |
| SCHEMBL16751908 | 0.75 | ALDH1A1 (0.49) | KDM4ERECQLCCR1ALDH1A1TP53 | |
| SCHEMBL15491596 | 0.75 | KDM4E (0.46) | KDM4ERECQLCCR1TDP1NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10342781-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2019-07-09 | — | — | US | disclosed |
| US-10342781-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2019-07-09 | — | — | US | disclosed |
| US-20180369213-A1 | ANTAGONISTS OF CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. | 2018-12-27 | — | — | US | disclosed |
| EP-2888261-B1 | ANTAGONISTS OF CHEMOKINE RECEPTORS | CHEMOCENTRYX INC (US) | 2018-04-18 | — | — | EP | disclosed |
| US-20180071257-A1 | DIAZOLE AMIDES | CHEMOCENTRYX, INC. | 2018-03-15 | — | — | US | disclosed |
| US-9750722-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-9750722-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-9750722-B2 | Diazole amides | CHEMOCENTRYX, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-20160193191-A1 | ANTAGONISTS OF CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. | 2016-07-07 | — | — | US | disclosed |
| US-20160193191-A1 | ANTAGONISTS OF CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. | 2016-07-07 | — | — | US | disclosed |
| WO-2014100735-A2 | DIAZOLE AMIDES | CHEMOCENTRYX, INC. (US) | 2014-06-26 | — | — | WO | disclosed |
| US-20140179733-A1 | DIAZOLE AMIDES | CHEMOCENTRYX, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| WO-2014035967-A2 | ANTAGONISTS OF CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. (US) | 2014-03-06 | — | — | WO | disclosed |
| US-20140057937-A1 | ANTAGONISTS OF CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| US-20140057937-A1 | ANTAGONISTS OF CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| US-20140057937-A1 | ANTAGONISTS OF CHEMOKINE RECEPTORS | CHEMOCENTRYX, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| EP-2280965-B1 | THIAZOL-4-CARBOXYLIC ACID ESTERS AND THIOESTERS AS PLANT PROTECTION AGENTS | BAYER CROPSCIENCE AG (DE) | 2012-08-29 | — | — | EP | disclosed |
| US-20110105429-A1 | Thiazole-4-Carboxylic Acid Esters and Thioesters as Plant Protection Agents | BAYER CROPSCIENCE AG (DE) | 2011-05-05 | — | — | US | disclosed |
| EP-2280965-A1 | THIAZOL-4-CARBOXYLIC ACID ESTERS AND THIOESTERS AS PLANT PROTECTION AGENTS | BAYER CROPSCIENCE AG (DE) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009132785-A1 | THIAZOL-4-CARBOXYLIC ACID ESTERS AND THIOESTERS AS PLANT PROTECTION AGENTS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT | 2009-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160193191-A1 | ANTAGONISTS OF CHEMOKINE RECEPTORS | CCR1, CCR3, CCR2 | KDM4E 4682/4885RECQL 4014/4885CCR1 1/4885 |
| US-20180071257-A1 | DIAZOLE AMIDES | CCR1, CCRL2, CCR4 | KDM4E 3623/4885RECQL 2677/4885CCR1 1/4885 |
| US-20180369213-A1 | ANTAGONISTS OF CHEMOKINE RECEPTORS | CCR1, CCR3, CCR2 | KDM4E 4682/4885RECQL 4014/4885CCR1 1/4885 |
| US-10342781-B2 | Diazole amides | CCR1, CCRL2, CCR4 | KDM4E 3623/4885RECQL 2677/4885CCR1 1/4885 |
| US-20140179733-A1 | DIAZOLE AMIDES | CCR1, CCRL2, CCR4 | KDM4E 3623/4885RECQL 2677/4885CCR1 1/4885 |
| US-20110105429-A1 | Thiazole-4-Carboxylic Acid Esters and Thioesters as Plant Protection Agents | ACOT7, LYPLA1, PPT1 | KDM4E 1123/4885RECQL 1610/4885CCR1 2014/4885 |
| US-20140057937-A1 | ANTAGONISTS OF CHEMOKINE RECEPTORS | CCR1, CCR3, CCR2 | KDM4E 4682/4885RECQL 4014/4885CCR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.