Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 1/20 | 0.45 |
| ▸ | FPR3 | P25089 | 10/20 | 0.44 |
| ▸ | FPR2 | P25090 | 10/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GLS | O94925 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21516509 | 0.76 | CDK2 (0.45) | SMN1; SMN2GLSCCNE1CDK2CDK5 | |
| SCHEMBL1000186 | 0.75 | FPR2 (0.44) | FPR3FPR2SMN1; SMN2MAPK10CCNE1 | |
| SCHEMBL20270816 | 0.74 | SMN1; SMN2 (0.58) | FPR3FPR2SMN1; SMN2MAPK10CCNE1 | |
| SCHEMBL13390860 | 0.74 | CCNE1 (0.66) | FFAR2FPR3FPR2SMN1; SMN2MAPK10 | |
| SCHEMBL16751979 | 0.73 | IDO1 (0.39) | FPR3FPR2SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL999552 | 0.70 | FPR3 (0.41) | FPR3FPR2SMN1; SMN2MAPK10CCNE1 | |
| SCHEMBL2646083 | 0.70 | GCK (0.69) | — | |
| SCHEMBL2646223 | 0.70 | GCK (0.69) | — | |
| SCHEMBL6729 | 0.70 | CCNE1 (0.59) | FFAR2SMN1; SMN2MAPK10MEN1ALDH1A1 | |
| SCHEMBL998766 | 0.69 | FPR3 (0.42) | FPR3FPR2SMN1; SMN2MAPK10CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3896068-A1 | S1P3 ANTAGONISTS | Teva Pharmaceutical Industries Limited (IL) | 2021-10-20 | — | — | EP | disclosed |
| EP-3689864-A1 | S1P3 ANTAGONISTS | Teva Pharmaceutical Industries Limited (IL) | 2020-08-05 | — | — | EP | disclosed |
| EP-3086845-B1 | S1P3 ANTAGONISTS | TEVA PHARMACEUTICAL INDUSTRIES LTD (IL) | 2019-11-20 | — | — | EP | disclosed |
| EP-2878339-A1 | SIP3 antagonists | Siena Biotech S.p.A. (IT) | 2015-06-03 | — | — | EP | disclosed |