SCHEMBL1675388

SCHEMBL1675388

Cc1ccc(-c2nc3cc(C(=O)O)ccc3o2)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 8/20 0.68
KDM4E B2RXH2 7/20 0.68
ALDH1A1 P00352 7/20 0.68
HPGD P15428 6/20 0.68
RAB9A P51151 6/20 0.68
NPC1 O15118 5/20 0.68
TP53 P04637 5/20 0.68
HSD17B10 Q99714 4/20 0.68
MAPT P10636 5/20 0.61
NFKB1 P19838 3/20 0.61
NFKB2 Q00653 3/20 0.61
RELA Q04206 3/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
LMNA P02545 1/20 0.61
POLB P06746 1/20 0.60
CASP3 P42574 1/20 0.60
SENP8 Q96LD8 1/20 0.60
SENP7 Q9BQF6 1/20 0.60
SENP6 Q9GZR1 1/20 0.60
GAA P10253 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9797021 0.93 HDAC6 (0.65) SMN1; SMN2RAB9ATP53MAPTHDAC6
SCHEMBL13135790 0.91 HDAC6 (0.63) SMN1; SMN2RAB9ATP53MAPTHDAC6
Hydrochloric Acid SCHEMBL17985190 0.90 HDAC6 (0.62) SMN1; SMN2RAB9ATP53MAPTHDAC6
SCHEMBL23513405 0.89 SMN1; SMN2 (0.68) SMN1; SMN2KDM4EALDH1A1HPGDRAB9A
SCHEMBL31261529 0.89 TTR (0.67) SMN1; SMN2KDM4EALDH1A1HPGDRAB9A
SCHEMBL11563299 0.87 SMN1; SMN2 (0.66) SMN1; SMN2KDM4EALDH1A1HPGDRAB9A
SCHEMBL2244471 0.87 SMN1; SMN2 (0.66) SMN1; SMN2KDM4EALDH1A1HPGDRAB9A
SCHEMBL12171536 0.87 HDAC6 (0.63) SMN1; SMN2RAB9ATP53MAPTHDAC6
SCHEMBL1675540 0.87 HDAC6 (0.71) SMN1; SMN2KDM4EALDH1A1HPGDRAB9A
SCHEMBL445014 0.87 HDAC6 (0.74) SMN1; SMN2KDM4EALDH1A1HPGDRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024225738-A1 BENZOXAZOLE DERIVATIVE COMPOUND HAVING DUAL AGONISTIC ACTIVITY ON FXR/PPAR ALPHA FOR TREATMENT OR PREVENTION OF FATTY LIVER DISEASE 부산대학교 산학협력단 2024-10-31 WO claimed
US-20140135305-A1 METHODS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS, INC. (US) 2014-05-15 US claimed
US-20110086833-A1 METHODS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS, INC. 2011-04-14 US claimed
WO-2009151546-A2 METHODS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS, INC. (US) 2009-12-17 WO claimed
WO-2024225738-A1 BENZOXAZOLE DERIVATIVE COMPOUND HAVING DUAL AGONISTIC ACTIVITY ON FXR/PPAR ALPHA FOR TREATMENT OR PREVENTION OF FATTY LIVER DISEASE 부산대학교 산학협력단 2024-10-31 WO disclosed
EP-3251694-A1 DRUG COMBINATIONS FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY Summit (Oxford) Limited (GB) 2017-12-06 EP disclosed
US-20160199357-A1 METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH PTC THERAPEUTICS, INC. 2016-07-14 US disclosed
US-20160199357-A1 METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH PTC THERAPEUTICS, INC. 2016-07-14 US disclosed
US-9289398-B2 Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith PTC THERAPEUTICS, INC. (US) 2016-03-22 US disclosed
US-9289398-B2 Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith PTC THERAPEUTICS, INC. (US) 2016-03-22 US disclosed
EP-1986633-B1 TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY SUMMIT CORP PLC (GB) 2014-07-30 EP disclosed
US-20140135305-A1 METHODS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS, INC. (US) 2014-05-15 US disclosed
WO-2009019504-A1 DRUG COMBINATIONS FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY SUMMIT CORPORATION PLC (GB) 2009-02-12 WO disclosed
EP-1986633-A2 TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY Summit Corporation Plc (GB) 2008-11-05 EP disclosed
US-20080269191-A1 Compounds for Nonsense Suppression, Use of These Compounds for the Manufacture of a Medicament for Treating Somatic Mutation-Related Diseases PTC THERAPEUTICS, INC. (US) 2008-10-30 US disclosed
US-20080269191-A1 Compounds for Nonsense Suppression, Use of These Compounds for the Manufacture of a Medicament for Treating Somatic Mutation-Related Diseases PTC THERAPEUTICS, INC. (US) 2008-10-30 US disclosed
WO-2007117438-A2 METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH PTC THERAPEUTICS, INC. (US) 2007-10-18 WO disclosed
WO-2007091106-A2 TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY SUMMIT CORPORATION PLC (GB) 2007-08-16 WO disclosed
US-4169837-A BICHROMOPHORIC BENZOXAZOLE ULTRAVIOLET STABILIZERS EASTMAN KODAK COMPANY (US) 1979-10-02 US disclosed
US-4029670-A Polychromophoric heterocyclic ultraviolet stabilizers EASTMAN KODAK COMPANY (US) 1977-06-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110086833-A1 METHODS FOR TREATING SPINAL MUSCULAR ATROPHY SMN1; SMN2, NSUN2, SNRPB2 SMN1; SMN2 1/4885KDM4E 2454/4885ALDH1A1 2971/4885
US-20160199357-A1 METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH UPF1, DNAJC10, RNGTT SMN1; SMN2 546/4885KDM4E 3746/4885ALDH1A1 3907/4885
US-20080269191-A1 Compounds for Nonsense Suppression, Use of These Compounds for the Manufacture of a Medicament for Treating Somatic Mutation-Related Diseases UPF1, NSUN2, RNMT SMN1; SMN2 86/4885KDM4E 1079/4885ALDH1A1 2558/4885
US-20140135305-A1 METHODS FOR TREATING SPINAL MUSCULAR ATROPHY SMN1; SMN2, NSUN2, SNRPB2 SMN1; SMN2 1/4885KDM4E 2454/4885ALDH1A1 2971/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.