Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CRHBP | P24387 | 1/20 | 0.57 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16756260 | 1.00 | MAPT (0.59) | MAPTALDH1A1SMN1; SMN2HPGDCRHBP | |
| SCHEMBL16756528 | 1.00 | MAPT (0.59) | MAPTALDH1A1SMN1; SMN2HPGDCRHBP | |
| SCHEMBL19553760 | 0.84 | MAPT (0.55) | MAPTALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL14247380 | 0.80 | ALDH1A1 (0.62) | MAPTALDH1A1SMN1; SMN2HPGDCRHBP | |
| SCHEMBL5021179 | 0.80 | ALDH1A1 (0.62) | MAPTALDH1A1SMN1; SMN2HPGDCRHBP | |
| SCHEMBL14247611 | 0.80 | ALDH1A1 (0.62) | MAPTALDH1A1SMN1; SMN2HPGDCRHBP | |
| SCHEMBL16756291 | 0.80 | ALDH1A1 (0.62) | MAPTALDH1A1SMN1; SMN2HPGDCRHBP | |
| SCHEMBL3049997 | 0.79 | CRHBP (0.71) | MAPTALDH1A1SMN1; SMN2HPGDCRHBP | |
| SCHEMBL29036921 | 0.78 | CRHBP (0.52) | MAPTALDH1A1SMN1; SMN2HPGDCRHBP | |
| SCHEMBL15540072 | 0.77 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2HPGDCRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858983-B1 | TNF-ALPHA MODULATING BENZIMIDAZOLES | UCB BIOPHARMA SPRL (BE) | 2018-04-18 | — | — | EP | disclosed |
| US-9550737-B2 | TNF -α modulating benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2017-01-24 | — | — | US | disclosed |
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | TNF, TNFRSF1A, NFKBIA | MAPT 1350/4885ALDH1A1 317/4885SMN1; SMN2 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.