Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.71 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.60 |
| ▸ | MAPT | P10636 | 10/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10484120 | 0.89 | CRHBP (0.58) | CRHBPCRHR2ALDH1A1MAPTHTR6 | |
| SCHEMBL30274042 | 0.82 | HCAR3 (0.55) | CRHBPCRHR2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL103504 | 0.82 | HCAR3 (0.55) | CRHBPCRHR2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5021179 | 0.82 | ALDH1A1 (0.62) | CRHBPCRHR2ALDH1A1MAPTHTR6 | |
| SCHEMBL14247611 | 0.82 | ALDH1A1 (0.62) | CRHBPCRHR2ALDH1A1MAPTHTR6 | |
| SCHEMBL16756291 | 0.82 | ALDH1A1 (0.62) | CRHBPCRHR2ALDH1A1MAPTHTR6 | |
| SCHEMBL14247380 | 0.82 | ALDH1A1 (0.62) | CRHBPCRHR2ALDH1A1MAPTHTR6 | |
| Ammonia Solution, Strong SCHEMBL28179606 | 0.81 | HCAR3 (0.54) | CRHBPCRHR2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL30128459 | 0.79 | KMT2A (0.53) | CRHBPCRHR2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL128849 | 0.79 | KMT2A (0.53) | CRHBPCRHR2ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111704579-B | Benzimidazole compound synthesis method based on iron-catalyzed redox coupling reaction | 中国农业大学 | 2021-12-14 | — | — | CN | disclosed |
| CN-111704579-A | Benzimidazole compound synthesis method based on iron-catalyzed redox coupling reaction | 中国农业大学 | 2020-09-25 | — | — | CN | disclosed |
| EP-2858983-B1 | TNF-ALPHA MODULATING BENZIMIDAZOLES | UCB BIOPHARMA SPRL (BE) | 2018-04-18 | — | — | EP | disclosed |
| EP-2479282-B1 | Media including nitroreductase enzymatic substrates | BIOMERIEUX SA (FR) | 2018-03-28 | — | — | EP | disclosed |
| US-9550737-B2 | TNF -α modulating benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2017-01-24 | — | — | US | disclosed |
| EP-2155893-B1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | BIOMERIEUX SA (FR) | 2016-10-19 | — | — | EP | disclosed |
| EP-2471944-B1 | Novel peptidase substrates | BIOMERIEUX SA (FR) | 2016-09-14 | — | — | EP | disclosed |
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2015-06-04 | — | — | US | disclosed |
| EP-2861590-A1 | COMPOUND AS WNT SIGNALING INHIBITOR, COMPOSITION, AND USE THEREOF | Curegenix Inc. (CN) | 2015-04-22 | — | — | EP | disclosed |
| EP-2858983-A1 | TNF -ALPHA MODULATING BENZIMIDAZOLES | UCB Biopharma SPRL (BE) | 2015-04-15 | — | — | EP | disclosed |
| EP-2479282-A1 | Media including nitroreductase enzymatic substrates | bioMérieux (FR) | 2012-07-25 | — | — | EP | disclosed |
| US-8216800-B2 | Substrates for detecting peptidase activity and methods using the substrates | BIOMERIEUX (FR) | 2012-07-10 | — | — | US | disclosed |
| EP-2471944-A1 | Novel peptidase substrates | bioMérieux (FR) | 2012-07-04 | — | — | EP | disclosed |
| US-8211662-B2 | Nitroreductase enzymatic substrates | BIOMERIEUX (FR) | 2012-07-03 | — | — | US | disclosed |
| US-20100221764-A1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | BIOMERIEUX (FR) | 2010-09-02 | — | — | US | disclosed |
| US-20100099128-A1 | NOVEL PEPTIDASE SUBSTRATES | BIOMERIEUX (FR) | 2010-04-22 | — | — | US | disclosed |
| EP-2155892-A2 | NOVEL PEPTIDASE SUBSTRATES | BIOMERIEUX (FR) | 2010-02-24 | — | — | EP | disclosed |
| EP-2155893-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | BIOMERIEUX (FR) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008152306-A2 | NOVEL PEPTIDASE SUBSTRATES | bioMérieux (FR) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008152305-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | bioMérieux (FR) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | TNF, TNFRSF1A, NFKBIA | CRHBP 3018/4885CRHR2 4315/4885ALDH1A1 317/4885 |
| US-20100221764-A1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | CBR1, CBR3, XDH | CRHBP 2080/4885CRHR2 1119/4885ALDH1A1 576/4885 |
| US-20100099128-A1 | NOVEL PEPTIDASE SUBSTRATES | XPNPEP1, DPEP1, DDAH1 | CRHBP 749/4885CRHR2 1463/4885ALDH1A1 3548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.