Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.71 |
| ▸ | RAB9A | P51151 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | SCD | O00767 | 6/20 | 0.70 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.69 |
| ▸ | PRKDC | P78527 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | ATR | Q13535 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | FADS1 | O60427 | 1/20 | 0.61 |
| ▸ | MMP2 | P08253 | 1/20 | 0.60 |
| ▸ | MMP9 | P14780 | 1/20 | 0.60 |
| ▸ | MMP8 | P22894 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30424949 | 1.00 | NPC1 (0.71) | NPC1RAB9AMEN1KMT2ASCD | |
| SCHEMBL12568427 | 0.91 | SCD (0.71) | NPC1RAB9AMEN1KMT2ASCD | |
| SCHEMBL6517599 | 0.84 | HDAC6 (0.69) | NPC1RAB9AMEN1KMT2ASCD | |
| SCHEMBL29386825 | 0.83 | NPC1 (0.88) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL2178266 | 0.83 | NPC1 (0.88) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL913121 | 0.82 | SCD (1.00) | SCDNPBWR1FADS1 | |
| SCHEMBL14254530 | 0.82 | NPBWR1 (1.00) | SCDNPBWR1FADS1 | |
| SCHEMBL12568424 | 0.82 | NPBWR1 (0.79) | SCDNPBWR1FADS1 | |
| SCHEMBL24295036 | 0.81 | NPC1 (0.84) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL7270916 | 0.81 | SCD (0.64) | NPC1RAB9AMEN1KMT2ASCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550737-B2 | TNF -α modulating benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2017-01-24 | — | — | US | disclosed |
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | TNF, TNFRSF1A, NFKBIA | NPC1 3216/4885RAB9A 1951/4885MEN1 3836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.