Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16760066 | 0.80 | HSD17B10 (0.42) | LMNAHTR2AGAAHPGD | |
| SCHEMBL701885 | 0.76 | LMNA (0.46) | SIRT1GPR84HTR6LMNACYP1A2 | |
| SCHEMBL11232989 | 0.75 | GPR84 (0.41) | SIRT1GPR84LMNAHTR2ACYP1A2 | |
| SCHEMBL640081 | 0.73 | KIF11 (0.39) | GPR84CYP1A2HPGD | |
| SCHEMBL7484865 | 0.72 | GPR84 (0.36) | GPR84HTR2ATRPM8 | |
| SCHEMBL208039 | 0.72 | GPR84 (0.39) | SIRT1GPR84LMNAHTR2ACYP1A2 | |
| SCHEMBL207498 | 0.72 | GPR84 (0.39) | SIRT1GPR84LMNAHTR2ACYP1A2 | |
| SCHEMBL210595 | 0.68 | LMNA (0.42) | SIRT1GPR84LMNACYP1A2GAA | |
| SCHEMBL15283206 | 0.67 | MEN1 (0.47) | LMNAHPGD | |
| SCHEMBL207953 | 0.66 | GFER (0.43) | SIRT1LMNACYP1A2GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3074385-A1 | PIPERIDINE DERIVATIVES FOR USE IN THE TREATMENT OR PREVENTION OF PSYCHIATRIC AND NEUROLOGICAL CONDITIONS | Takeda Pharmaceutical Company Limited (JP) | 2016-10-05 | — | — | EP | disclosed |
| WO-2015079224-A1 | PIPERIDINE DERIVATIVES FOR USE IN THE TREATMENT OR PREVENTION OF PSYCHIATRIC AND NEUROLOGICAL CONDITIONS | TAKEDA CAMBRIDGE LIMITED (GB) | 2015-06-04 | — | — | WO | disclosed |