Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 3/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16763339 | 1.00 | GABRB1 (0.47) | GABRB1GABRB2CTSKCTSSALDH1A1 | |
| SCHEMBL14820895 | 0.87 | CTSK (0.57) | GABRB1GABRB2CTSKCTSSALDH1A1 | |
| SCHEMBL15783776 | 0.85 | CTSK (0.48) | GABRB1GABRB2CTSKCTSSGAA | |
| SCHEMBL320557 | 0.85 | CTSK (0.48) | GABRB1GABRB2CTSKCTSSALDH1A1 | |
| SCHEMBL14240829 | 0.85 | CTSK (0.48) | GABRB1GABRB2CTSKCTSSGAA | |
| SCHEMBL505937 | 0.85 | CTSK (0.48) | GABRB1GABRB2CTSKCTSSALDH1A1 | |
| SCHEMBL15783777 | 0.85 | CTSK (0.48) | GABRB1GABRB2CTSKCTSSGAA | |
| SCHEMBL16791251 | 0.84 | HPGDS (0.49) | GABRB1GABRB2CTSKCTSSLMNA | |
| SCHEMBL8183661 | 0.82 | HPGDS (0.50) | CTSKCTSSPPARGPPARAATM | |
| SCHEMBL321824 | 0.82 | KCNK3 (0.48) | GABRB1GABRB2CTSKCTSSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077386-B1 | BENZHYDRYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES | CHIESI FARM SPA (IT) | 2017-09-06 | — | — | EP | disclosed |
| EP-3077386-A1 | BENZHYDRYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES | Chiesi Farmaceutici S.p.A. (IT) | 2016-10-12 | — | — | EP | disclosed |
| US-9145409-B2 | Benzhydryl derivatives | CHIESI FARMACEUTICI S.P.A (IT) | 2015-09-29 | — | — | US | disclosed |
| WO-2015082619-A1 | BENZHYDRYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-06-11 | — | — | WO | disclosed |
| US-20150158857-A1 | BENZHYDRYL DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158857-A1 | BENZHYDRYL DERIVATIVES | PDE4A, PDE4B, PDE3A | GABRB1 866/4885GABRB2 933/4885CTSK 2017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.