Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 15/20 | 0.67 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16800298 | 0.84 | ABCB1 (0.71) | ABCB1ABCG2ADORA2AMEN1ALDH1A1 | |
| SCHEMBL13815718 | 0.82 | DPP4 (0.49) | ABCB1ABCG2ADORA2AMEN1ALDH1A1 | |
| SCHEMBL5455512 | 0.77 | PDE10A (0.54) | ABCB1ADORA2AMEN1ALDH1A1KMT2A | |
| SCHEMBL13263646 | 0.76 | NPC1 (0.53) | MEN1ALDH1A1KMT2AKDM4EMAPT | |
| SCHEMBL16386072 | 0.76 | ALDH1A1 (0.50) | ADORA2AMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL7063800 | 0.74 | RAB9A (0.71) | MEN1ALDH1A1KMT2AKDM4EMAPT | |
| SCHEMBL3299677 | 0.73 | TP53 (0.53) | MEN1ALDH1A1KMT2AKDM4EMAPT | |
| SCHEMBL23413228 | 0.71 | PTGS1 (0.51) | ABCB1ADORA2A | |
| SCHEMBL23998420 | 0.71 | ABCB1 (0.49) | ABCB1ABCG2ADORA2AMEN1ALDH1A1 | |
| SCHEMBL8549227 | 0.71 | MYC (0.70) | ABCB1ADORA2AMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160244457-A1 | SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT | UNIV KANSAS (US) | 2016-08-25 | — | — | US | disclosed |
| US-20160244457-A1 | SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT | UNIV KANSAS (US) | 2016-08-25 | — | — | US | disclosed |
| US-20160244457-A1 | SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT | UNIV KANSAS (US) | 2016-08-25 | — | — | US | disclosed |
| US-20150197526-A1 | SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT | UNIVERSITY OF KANSAS | 2015-07-16 | — | — | US | disclosed |
| US-20150197526-A1 | SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT | UNIVERSITY OF KANSAS | 2015-07-16 | — | — | US | disclosed |
| US-20150197526-A1 | SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT | UNIVERSITY OF KANSAS | 2015-07-16 | — | — | US | disclosed |
| US-9056111-B1 | Selective efflux inhibitors and related pharmaceutical compositions and methods of treatment | STC.UNM (US) | 2015-06-16 | — | — | US | disclosed |
| US-9056111-B1 | Selective efflux inhibitors and related pharmaceutical compositions and methods of treatment | STC.UNM (US) | 2015-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150197526-A1 | SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT | ABCB1, ABCG2, ABCC5 | ABCB1 1/4885ABCG2 2/4885ADORA2A 153/4885 |
| US-20160244457-A1 | SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT | ABCB1, ABCG2, ABCC5 | ABCB1 1/4885ABCG2 2/4885ADORA2A 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.