Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | COMT | P21964 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19837518 | 0.83 | NOTUM (0.38) | NOTUMALDH1A1PLAUKDM4EPOLB | |
| SCHEMBL29435663 | 0.78 | PIK3R1 (0.41) | NOTUMALDH1A1PIK3CDIDO1HTR3E | |
| SCHEMBL1515470 | 0.78 | PIK3R1 (0.41) | NOTUMALDH1A1PIK3CDIDO1HTR3E | |
| SCHEMBL13274209 | 0.77 | COMT (0.40) | NOTUMALDH1A1SMN1; SMN2PIK3CDIDO1 | |
| SCHEMBL18301718 | 0.75 | COMT (0.39) | NOTUMALDH1A1PLAUPIK3CDIDO1 | |
| SCHEMBL15019715 | 0.75 | MBOAT4 (0.34) | NOTUML3MBTL1 | |
| SCHEMBL28063333 | 0.75 | PIK3CD (0.34) | ALDH1A1KDM4EPOLBSMN1; SMN2PIK3CD | |
| SCHEMBL4372965 | 0.75 | PIK3CD (0.38) | NOTUMALDH1A1PIK3CDIDO1HTR3E | |
| SCHEMBL600673 | 0.75 | PIK3CD (0.49) | NOTUMALDH1A1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL30488644 | 0.74 | ASPH (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015078374-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2015-06-04 | — | — | WO | disclosed |