SCHEMBL16772452

SCHEMBL16772452

Oc1c(-c2ccccc2)cc2cc(-c3ccccc3)ccc2c1-c1c(O)c(-c2ccccc2)cc2cc(-c3ccccc3)ccc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 5/20 0.53
ESR2 Q92731 5/20 0.53
GRIN2D O15399 1/20 0.49
GRIN2A Q12879 1/20 0.49
GRIN2B Q13224 1/20 0.49
GRIN2C Q14957 1/20 0.49
HSD17B1 P14061 4/20 0.49
HSD17B2 P37059 4/20 0.49
CYP1A2 P05177 2/20 0.47
CYP3A4 P08684 2/20 0.47
CYP2D6 P10635 2/20 0.47
CYP2C9 P11712 2/20 0.47
CYP2B6 P20813 2/20 0.47
CYP2C19 P33261 2/20 0.47
GPR84 Q9NQS5 4/20 0.45
ALOX5 P09917 1/20 0.42
PTPN1 P18031 1/20 0.42
BACE1 P56817 2/20 0.42
KDM4E B2RXH2 2/20 0.41
MEN1 O00255 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19821131 0.91 GRIN2D (0.49) ESR1ESR2GRIN2DGRIN2AGRIN2B
SCHEMBL29510114 0.83 MEN1 (0.58) HSD17B1HSD17B2GPR84ALOX5BACE1
SCHEMBL30275493 0.83 MEN1 (0.58) HSD17B1HSD17B2GPR84ALOX5BACE1
SCHEMBL3262604 0.83 MEN1 (0.58) HSD17B1HSD17B2GPR84ALOX5BACE1
SCHEMBL16772451 0.83 GPR84 (0.43) ESR1ESR2HSD17B1HSD17B2CYP1A2
SCHEMBL14327785 0.79 GPR84 (0.50) ESR1ESR2HSD17B1HSD17B2GPR84
SCHEMBL3918767 0.79 PTPN1 (0.41) ESR1ESR2GRIN2DGRIN2AGRIN2B
SCHEMBL3922384 0.78 MEN1 (0.53) ESR1ESR2HSD17B1HSD17B2GPR84
SCHEMBL14327802 0.78 ALOX5 (0.51) ESR1ESR2HSD17B1HSD17B2CYP1A2
SCHEMBL29805130 0.78 MEN1 (0.53) ESR1ESR2HSD17B1HSD17B2GPR84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150152332-A1 LIQUID CRYSTAL COMPOSITION, POLYMER, FILM, AND CHOLESTERIC LIQUID CRYSTAL FUJIFILM CORPORATION (JP) 2015-06-04 US disclosed
US-20150152332-A1 LIQUID CRYSTAL COMPOSITION, POLYMER, FILM, AND CHOLESTERIC LIQUID CRYSTAL FUJIFILM CORPORATION (JP) 2015-06-04 US disclosed