Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ADH5 | P11766 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10195813 | 0.88 | ADH5 (0.63) | ADH5TSHRRXRA | |
| SCHEMBL182048 | 0.86 | CA1 (0.57) | ADH5ALDH1A1CA1CA2KDM4E | |
| SCHEMBL182128 | 0.84 | HTT (0.49) | HTTALDH1A1PTPN1CA12CA1 | |
| SCHEMBL182280 | 0.84 | ADH5 (0.55) | HTTADH5ALDH1A1CA12CA1 | |
| SCHEMBL181958 | 0.83 | ALDH1A1 (0.57) | ADH5ALDH1A1KDM4ERXRAMEN1 | |
| SCHEMBL182263 | 0.82 | ADH5 (0.55) | ADH5EGFRTSHR | |
| SCHEMBL204640 | 0.81 | TSHR (0.61) | ALDH1A1PTPN1CA12CA1CA2 | |
| SCHEMBL2710630 | 0.81 | BCL2L1 (0.62) | ADH5KDM4ERXRAMEN1KMT2A | |
| SCHEMBL182188 | 0.81 | ADH5 (0.55) | ADH5ALDH1A1KDM4ETSHRRXRA | |
| SCHEMBL181985 | 0.80 | ADH5 (0.51) | ADH5ALDH1A1HPGDRXRAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051342-B2 | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation related diseases | PTC THERAPEUTICS, INC. (US) | 2015-06-09 | — | — | US | disclosed |