Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.49 |
| ▸ | RXRA | P19793 | 2/20 | 0.45 |
| ▸ | RXRB | P28702 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2709568 | 0.90 | EPHX2 (0.48) | KMORXRARXRBEPHX2HDAC1 | |
| SCHEMBL181683 | 0.81 | KMO (0.51) | KMORXRARXRBLMNAGAA | |
| SCHEMBL10194254 | 0.81 | KMO (0.51) | KMORXRARXRBHDAC6AKR1C3 | |
| SCHEMBL16775438 | 0.80 | RXRA (0.52) | KMORXRARXRBHDAC1HDAC6 | |
| SCHEMBL182385 | 0.79 | KMO (0.51) | KMORXRARXRBLMNAMEN1 | |
| SCHEMBL16775447 | 0.79 | MEN1 (0.50) | KMORXRARXRBHDAC1HDAC6 | |
| SCHEMBL2709321 | 0.78 | KMO (0.48) | KMORXRARXRBAKR1C3AKR1C2 | |
| SCHEMBL182259 | 0.78 | TUBB4A (0.53) | KMOERN1NPC1RAB9A | |
| SCHEMBL2710868 | 0.78 | KMO (0.50) | KMORXRARXRBERN1MEN1 | |
| SCHEMBL2710486 | 0.76 | KMO (0.59) | KMORXRARXRBGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051342-B2 | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation related diseases | PTC THERAPEUTICS, INC. (US) | 2015-06-09 | — | — | US | disclosed |