Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.38 |
| ▸ | GRM5 | P41594 | 5/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776230 | 0.95 | PRMT5 (0.39) | PRMT5WDR77GRM5PTGS1PTGS2 | |
| SCHEMBL16776046 | 0.90 | FAAH (0.35) | PRMT5WDR77GSK3BDYRK1ARPS6KA2 | |
| SCHEMBL16776048 | 0.88 | ABL1 (0.35) | GRM5FGFR4ABL1 | |
| SCHEMBL16776477 | 0.88 | PTGS1 (0.40) | PTGS1PTGS2GSK3BFAAHNTRK1 | |
| SCHEMBL16776014 | 0.87 | GRM5 (0.40) | GRM5PTGS1PTGS2GSK3BDYRK1A | |
| SCHEMBL16776240 | 0.86 | WNT1 (0.35) | PRMT5WDR77GSK3BDYRK1AHDAC8 | |
| SCHEMBL16776037 | 0.85 | FGFR4 (0.37) | GSK3BDYRK1ARPS6KA2FAAHHDAC8 | |
| SCHEMBL16776246 | 0.85 | RPS6KA2 (0.35) | PRMT5WDR77GSK3BDYRK1ARPS6KA2 | |
| SCHEMBL16776124 | 0.85 | CNR2 (0.38) | GRM5PTGS1PTGS2GSK3BDYRK1A | |
| SCHEMBL16776280 | 0.85 | GSK3B (0.40) | PTGS1PTGS2GSK3BDYRK1ARPS6KA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | PRMT5 209/4885WDR77 1434/4885GRM5 3471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.