Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776074 | 0.92 | KARS1 (0.43) | VCPKARS1FAAHMAP3K12CLK2 | |
| SCHEMBL16776071 | 0.91 | VCP (0.39) | VCPFGFR4KARS1TRPV1CLK2 | |
| SCHEMBL16776110 | 0.90 | KARS1 (0.39) | FGFR4KARS1RPS6KA3RPS6KA2TRPV1 | |
| SCHEMBL16776090 | 0.88 | FGFR4 (0.40) | VCPFGFR4KARS1RPS6KA2PHGDH | |
| SCHEMBL16776060 | 0.87 | FGFR4 (0.43) | VCPFGFR4KARS1RPS6KA3RPS6KA2 | |
| SCHEMBL16776079 | 0.85 | SLC5A1 (0.37) | VCPKARS1TRPV1CLK2LRRK2 | |
| SCHEMBL16775892 | 0.83 | FGFR4 (0.42) | FGFR4KARS1RPS6KA3RPS6KA2PHGDH | |
| SCHEMBL16775864 | 0.82 | FGFR4 (0.44) | VCPFGFR4RPS6KA3RPS6KA2TRPV1 | |
| SCHEMBL16775932 | 0.82 | FGFR4 (0.41) | FGFR4RPS6KA3RPS6KA2 | |
| SCHEMBL16776473 | 0.81 | FGFR4 (0.42) | FGFR4KARS1PHGDHSCN9ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | VCP 1270/4885FGFR4 1754/4885KARS1 1760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.