Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | CTPS1 | P17812 | 2/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776280 | 0.91 | GSK3B (0.40) | GSK3BDYRK1AARLRRK2RPS6KA2 | |
| SCHEMBL16776246 | 0.90 | RPS6KA2 (0.35) | GSK3BDYRK1AARRPS6KA2FAAH | |
| SCHEMBL16776188 | 0.87 | ATR (0.42) | GSK3BDYRK1ARPS6KA2FAAHJAK1 | |
| SCHEMBL16775980 | 0.86 | GRM5 (0.39) | GSK3BARLRRK2CPT1A | |
| SCHEMBL16776046 | 0.85 | FAAH (0.35) | GSK3BDYRK1AARRPS6KA2FAAH | |
| SCHEMBL16776261 | 0.84 | ABL1 (0.37) | GSK3BDYRK1ALRRK2ABL1CTPS1 | |
| SCHEMBL16776244 | 0.81 | ABL1 (0.40) | ABL1 | |
| SCHEMBL16776257 | 0.81 | RPS6KA2 (0.33) | GSK3BDYRK1AARLRRK2RPS6KA2 | |
| SCHEMBL16776230 | 0.80 | PRMT5 (0.39) | GSK3BDYRK1ARPS6KA2FGFR4FAAH | |
| SCHEMBL16776240 | 0.79 | WNT1 (0.35) | GSK3BDYRK1AMLLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | GSK3B 1728/4885DYRK1A 2623/4885AR 3677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.