Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 10/20 | 0.37 |
| ▸ | HTR2A | P28223 | 9/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16785562 | 0.93 | RPS6KA3 (0.38) | RPS6KA3RPS6KA2HTR2CHTR2ACACNA1G | |
| SCHEMBL16776383 | 0.90 | DYRK1A (0.35) | HTR2CHTR2ACACNA1GCACNA1HCACNA1I | |
| SCHEMBL16776384 | 0.90 | PRMT5 (0.39) | AR | |
| SCHEMBL16776399 | 0.86 | CREBBP (0.42) | HTR2CHTR2AHTR2BMEN1MAPT | |
| SCHEMBL16776393 | 0.85 | AR (0.34) | AR | |
| SCHEMBL16776394 | 0.82 | FAAH (0.34) | RPS6KA3RPS6KA2HTR2CHTR2AHTR2B | |
| SCHEMBL16776395 | 0.81 | TRPA1 (0.33) | — | |
| SCHEMBL16776388 | 0.81 | NPC1 (0.38) | CYP1A2CYP3A4MAPTCYP2C9CYP2C19 | |
| SCHEMBL16776387 | 0.81 | PTGS1 (0.35) | TRPV1MEN1KMT2AAR | |
| SCHEMBL16776389 | 0.78 | PIK3CA (0.33) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | RPS6KA3 2368/4885RPS6KA2 2318/4885HTR2C 4651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.