Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.65 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.65 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 6/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1678198 | 0.86 | KDM4E (0.51) | DPP4DPP8KDM4ECNR1CNR2 | |
| SCHEMBL12807245 | 0.79 | DPP4 (1.00) | DPP4DPP8SCN10A | |
| SCHEMBL14290492 | 0.73 | KMT2A (0.48) | KDM4EKMT2AHPGDMEN1LMNA | |
| SCHEMBL12807244 | 0.72 | DPP4 (1.00) | DPP4DPP8 | |
| SCHEMBL30692923 | 0.71 | MAPK8 (0.48) | DPP4DPP8SCN10ASCN1AKCNH2 | |
| SCHEMBL20568886 | 0.71 | MAPK8 (0.48) | DPP4DPP8SCN10ASCN1AKCNH2 | |
| SCHEMBL3061882 | 0.71 | ADORA1 (0.44) | DPP4DPP8KDM4EKMT2AHPGD | |
| SCHEMBL28329968 | 0.70 | KDM4E (0.51) | KDM4EKMT2AHPGDMEN1LMNA | |
| SCHEMBL293902 | 0.68 | GSK3A (0.44) | DPP4DPP8KDM4ECNR1KMT2A | |
| SCHEMBL16571158 | 0.67 | ALOX15 (0.49) | DPP4DPP8SCN10AKDM4ECNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308847-B1 | Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases | EMC MICROCOLLECTIONS GMBH (DE) | 2014-04-02 | — | — | EP | disclosed |
| EP-2308847-A1 | Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases | EMC microcollections GmbH (DE) | 2011-04-13 | — | — | EP | disclosed |
| EP-2308847-A1 | Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases | EMC microcollections GmbH (DE) | 2011-04-13 | — | — | EP | disclosed |