Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 3/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16571385 | 0.89 | ALOX15 (0.47) | ALOX15KMT2AMEN1CNR2GUSB | |
| SCHEMBL16571420 | 0.87 | ALOX15 (0.49) | ALOX15KDM4EKMT2ALMNAGAA | |
| SCHEMBL16571189 | 0.85 | KDM4E (0.43) | KDM4EDPP4DPP8KMT2AMEN1 | |
| SCHEMBL16571406 | 0.81 | PDE4A (0.41) | ALOX15SYKNUDT1 | |
| SCHEMBL16570654 | 0.80 | RIPK1 (0.41) | ALOX15KMT2AMEN1ALPL | |
| SCHEMBL19478398 | 0.79 | XDH (0.39) | ALOX15METKDRSYK | |
| SCHEMBL16571121 | 0.79 | XDH (0.39) | ALOX15NUDT1 | |
| SCHEMBL16571148 | 0.78 | NUDT1 (0.43) | ALOX15SYKNUDT1 | |
| SCHEMBL16571097 | 0.78 | CCNC (0.46) | ALOX15KDM4ELMNAHPGDSYK | |
| SCHEMBL16571417 | 0.78 | XDH (0.38) | ALOX15KDM4EKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044207-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015036412-A1 | INDOL-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-19 | — | — | WO | disclosed |