Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | IDE | P14735 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784644 | 0.94 | GALR3 (0.47) | GALR3SLC6A9KDM4ETDP1CARM1 | |
| SCHEMBL16229785 | 0.89 | DGAT1 (0.36) | SLC6A9KMT2AKCNH2 | |
| SCHEMBL16229802 | 0.89 | GALR3 (0.38) | GALR3SLC6A9CARM1PRMT6TRPV4 | |
| SCHEMBL16229781 | 0.88 | SLC6A9 (0.49) | GALR3SLC6A9KCNH2 | |
| SCHEMBL16229747 | 0.88 | SLC6A9 (0.43) | SLC6A9KCNH2 | |
| SCHEMBL16229771 | 0.88 | GALR3 (0.38) | GALR3SLC6A9KDM4ETDP1CARM1 | |
| SCHEMBL16229807 | 0.88 | SLC6A9 (0.36) | SLC6A9KCNH2 | |
| SCHEMBL16784643 | 0.84 | GALR3 (0.43) | GALR3SLC6A9CARM1PRMT6TRPV4 | |
| SCHEMBL16229787 | 0.84 | SLC6A9 (0.39) | GALR3SLC6A9CARM1PRMT6TRPV4 | |
| SCHEMBL16229810 | 0.84 | SLC6A9 (0.38) | GALR3SLC6A9KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |