Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | NR1D2 | Q14995 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
| ▸ | STK16 | O75716 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.33 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229785 | 0.93 | DGAT1 (0.36) | SLC6A9POLBKMT2ASMYD3KCNH2 | |
| SCHEMBL16784628 | 0.90 | SLC6A9 (0.44) | SLC6A9KMT2AGALR3GAKSTK16 | |
| SCHEMBL16784656 | 0.90 | SLC6A9 (0.35) | SLC6A9KMT2ACARM1PRMT6GALR3 | |
| SCHEMBL16784644 | 0.89 | GALR3 (0.47) | SLC6A9CARM1PRMT6GALR3GUSB | |
| SCHEMBL16229762 | 0.89 | KMT2A (0.32) | SLC6A9POLBKMT2ACARM1PRMT6 | |
| SCHEMBL16784634 | 0.87 | POLB (0.35) | SLC6A9POLBKMT2AALKBH5CARM1 | |
| SCHEMBL16784626 | 0.86 | SLC6A9 (0.50) | SLC6A9KCNH2 | |
| SCHEMBL16229799 | 0.84 | SLC6A9 (0.33) | SLC6A9KMT2ASMYD3KCNH2 | |
| SCHEMBL16229747 | 0.83 | SLC6A9 (0.43) | SLC6A9KCNH2LMNAMAPT | |
| SCHEMBL16229807 | 0.83 | SLC6A9 (0.36) | SLC6A9KCNH2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |