Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.49 |
| ▸ | HTR2C | P28335 | 9/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16775824 | 0.97 | HTR2A (0.50) | HTR2AHTR2CKITFAAHMEN1 | |
| SCHEMBL16775841 | 0.92 | CA2 (0.41) | HTR2AHTR2CKITMEN1KMT2A | |
| SCHEMBL16776358 | 0.92 | HTR2C (0.48) | HTR2AHTR2CKITMEN1KMT2A | |
| SCHEMBL16776476 | 0.91 | CA2 (0.43) | HTR2AHTR2CKITMEN1KMT2A | |
| SCHEMBL16785651 | 0.90 | CA2 (0.39) | HTR2AHTR2CKITMEN1KMT2A | |
| SCHEMBL16775829 | 0.90 | CA2 (0.41) | HTR2AHTR2CKITMEN1KMT2A | |
| SCHEMBL16776322 | 0.90 | NPC1 (0.44) | KITMEN1KMT2AMAPTCA2 | |
| SCHEMBL16776130 | 0.89 | HTR2C (0.48) | HTR2AHTR2CKITFAAHMEN1 | |
| SCHEMBL16776146 | 0.88 | HTR2C (0.48) | HTR2AHTR2C | |
| SCHEMBL16775833 | 0.88 | ALOX15 (0.46) | KITFAAHMEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | HTR2A 4386/4885HTR2C 4651/4885KIT 2844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.