Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | ITK | Q08881 | 3/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16765677 | 0.91 | HCAR2 (0.42) | HCAR2AURKAITKKLKB1FGFR4 | |
| SCHEMBL15565347 | 0.89 | HCAR2 (0.41) | HCAR2AURKAITKKLKB1FGFR4 | |
| SCHEMBL15564580 | 0.83 | HCAR2 (0.41) | HCAR2AURKAITKKLKB1NPC1 | |
| SCHEMBL15564844 | 0.78 | KLKB1 (0.40) | HCAR2KLKB1 | |
| SCHEMBL584369 | 0.75 | KLKB1 (0.35) | KLKB1 | |
| SCHEMBL16766379 | 0.75 | KLKB1 (0.40) | KLKB1 | |
| SCHEMBL15565602 | 0.74 | KLKB1 (0.38) | HCAR2KLKB1 | |
| SCHEMBL25287756 | 0.73 | DGAT1 (0.37) | KLKB1 | |
| SCHEMBL20299094 | 0.71 | DGAT1 (0.34) | KLKB1 | |
| SCHEMBL2893669 | 0.69 | L3MBTL1 (0.40) | KLKB1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160326142-A1 | PYRAZOLE CARBOXAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2016-11-10 | — | — | US | disclosed |
| US-20150158851-A1 | PYRAZOLE CARBOXAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2015-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158851-A1 | PYRAZOLE CARBOXAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | CYP3A5, GLP1R, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | HCAR2 154/4885AURKA 1154/4885ITK 3417/4885 |
| US-20160326142-A1 | PYRAZOLE CARBOXAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | CYP3A5, GLP1R, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | HCAR2 154/4885AURKA 1154/4885ITK 3417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.