Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16789073 | 0.93 | CYP2D6 (0.54) | CTSSCTSKCHRM3CHRM4CHRM2 | |
| SCHEMBL8512111 | 0.93 | CYP2D6 (0.54) | CTSSCTSKCHRM3CHRM4CHRM2 | |
| SCHEMBL8512117 | 0.93 | CYP2D6 (0.54) | CTSSCTSKCHRM3CHRM4CHRM2 | |
| SCHEMBL8516088 | 0.93 | CYP2D6 (0.54) | CTSSCTSKCHRM3CHRM4CHRM2 | |
| SCHEMBL16789065 | 0.88 | CTSK (0.51) | CTSSCTSKCHRM3CHRM4CHRM2 | |
| SCHEMBL6347304 | 0.87 | MMP2 (0.53) | CTSSCTSKCHRM3CHRM4CHRM2 | |
| SCHEMBL27770063 | 0.87 | MMP2 (0.53) | CTSSCTSKCHRM3CHRM4CHRM2 | |
| SCHEMBL16789066 | 0.87 | CYP2D6 (0.64) | CTSSCTSKMEN1KMT2ACYP2D6 | |
| SCHEMBL16789063 | 0.86 | BCHE (0.54) | CTSSCTSKMEN1KMT2AALDH1A1 | |
| SCHEMBL8512028 | 0.85 | LMNA (0.60) | CTSSCTSKCHRM3CHRM4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106459020-B | Amino ester derivatives | 奇斯药制品公司 | 2019-06-18 | — | — | CN | disclosed |
| US-10117860-B2 | Aminoester derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-11-06 | — | — | US | disclosed |
| EP-3152201-B1 | AMINOESTER DERIVATIVES | CHIESI FARM SPA (IT) | 2018-08-29 | — | — | EP | disclosed |
| US-20170340616-A1 | AMINOESTER DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-11-30 | — | — | US | disclosed |
| US-20170340616-A1 | AMINOESTER DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-11-30 | — | — | US | disclosed |
| EP-3077385-B1 | HETEROARYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES | CHIESI FARM SPA (IT) | 2017-10-04 | — | — | EP | disclosed |
| US-9763924-B2 | Aminoester derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-09-19 | — | — | US | disclosed |
| US-9763924-B2 | Aminoester derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-09-19 | — | — | US | disclosed |
| US-9763924-B2 | Aminoester derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-09-19 | — | — | US | disclosed |
| EP-3152201-A1 | AMINOESTER DERIVATIVES | Chiesi Farmaceutici S.p.A. (IT) | 2017-04-12 | — | — | EP | disclosed |
| US-20150352091-A1 | AMINOESTER DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-10 | — | — | US | disclosed |
| US-20150352091-A1 | AMINOESTER DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-10 | — | — | US | disclosed |
| US-20150352091-A1 | AMINOESTER DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-10 | — | — | US | disclosed |
| WO-2015185649-A1 | AMINOESTER DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-10 | — | — | WO | disclosed |
| WO-2015185649-A1 | AMINOESTER DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-10 | — | — | WO | disclosed |
| US-9133185-B2 | Heteroaryl derivatives | CHIESI FARMACEUTICI S.P.A (IT) | 2015-09-15 | — | — | US | disclosed |
| US-9133185-B2 | Heteroaryl derivatives | CHIESI FARMACEUTICI S.P.A (IT) | 2015-09-15 | — | — | US | disclosed |
| US-20150158858-A1 | HETEROARYL DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-06-11 | — | — | US | disclosed |
| US-20150158858-A1 | HETEROARYL DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-06-11 | — | — | US | disclosed |
| WO-2015082616-A1 | HETEROARYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340616-A1 | AMINOESTER DERIVATIVES | PDE4A, PDE4B, PDE3A | CTSS 2361/4885CTSK 2757/4885CHRM3 8/4885 |
| US-20150352091-A1 | AMINOESTER DERIVATIVES | PDE4A, PDE4B, PDE3A | CTSS 2361/4885CTSK 2757/4885CHRM3 8/4885 |
| US-20150158858-A1 | HETEROARYL DERIVATIVES | PDE4A, PDE4B, PDE3A | CTSS 1993/4885CTSK 2584/4885CHRM3 4/4885 |
| US-10117860-B2 | Aminoester derivatives | PDE4A, PDE4B, PDE3A | CTSS 2361/4885CTSK 2757/4885CHRM3 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.