Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29033517 | 0.85 | MEN1 (0.63) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL23046877 | 0.84 | MAPT (0.70) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL17897939 | 0.81 | MEN1 (0.41) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL22747549 | 0.79 | MTNR1A (0.53) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL29033496 | 0.79 | MTNR1A (0.53) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL22118353 | 0.76 | MEN1 (0.52) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL29033515 | 0.76 | MEN1 (0.46) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL29033497 | 0.74 | ESR1 (0.49) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL18160173 | 0.73 | ESR1 (0.52) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL22118368 | 0.73 | MEN1 (0.49) | MEN1KMT2AMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738623-B2 | Curcumin analogs | THE GENERAL HOSPITAL CORPORATION (US) | 2017-08-22 | — | — | US | disclosed |
| US-9738623-B2 | Curcumin analogs | THE GENERAL HOSPITAL CORPORATION (US) | 2017-08-22 | — | — | US | disclosed |
| US-20150158841-A1 | Curcumin Analogs | THE GENERAL HOSPITAL CORPORATION (US) | 2015-06-11 | — | — | US | disclosed |
| US-20150158841-A1 | Curcumin Analogs | THE GENERAL HOSPITAL CORPORATION (US) | 2015-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158841-A1 | Curcumin Analogs | APP, BACE1, PSEN1 | MEN1 3064/4885KMT2A 3054/4885MAPT 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.