SCHEMBL1679

SCHEMBL1679

CCOC(=O)C1(c2ccc(-c3ccc(-c4onc(C)c4CC(O)SCc4cccc(C(F)(F)F)c4)cc3)cc2)CC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 9/20 0.39
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
LMNA P02545 1/20 0.37
TSHR P16473 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
LPAR1 Q92633 3/20 0.35
ABCC3 O15438 1/20 0.35
ABCC4 O15439 1/20 0.35
ABCB11 O95342 1/20 0.35
CYP2C8 P10632 1/20 0.35
CYP2C9 P11712 1/20 0.35
ABCB4 P21439 1/20 0.35
ABCC2 Q92887 1/20 0.35
SLCO1B3 Q9NPD5 1/20 0.35
SLCO1B1 Q9Y6L6 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2285 0.91 LPAR1 (0.41) EPHX1LPAR1ABCC3ABCC4ABCB11
SCHEMBL1233 0.88 CYP2C9 (0.42) LMNATSHRNPSR1TDP1ALDH1A1
SCHEMBL2337 0.88 CYP2C9 (0.42) LMNATSHRNPSR1TDP1ALDH1A1
SCHEMBL2232 0.87 LMNA (0.39) MEN1KMT2ALMNATSHRNPSR1
SCHEMBL6871 0.85 EPHX1 (0.40) EPHX1MEN1KMT2AALDH1A1MAPT
SCHEMBL1678 0.84 MEN1 (0.39) EPHX1MEN1KMT2ALMNATSHR
SCHEMBL6632 0.84 OPRM1 (0.38) LMNATSHRNPSR1TDP1LPAR1
SCHEMBL7428 0.84 EPHX1 (0.40) EPHX1MEN1KMT2ATDP1ALDH1A1
SCHEMBL6585 0.82 EPHX1 (0.42) EPHX1LPAR1LPAR3
SCHEMBL1880 0.81 LPAR1 (0.40) MEN1KMT2ALMNATSHRNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
EP-2483253-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed
WO-2011041729-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed