Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 7/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428 | 0.92 | EPHX1 (0.40) | EPHX1SYKMEN1KMT2AALDH1A1 | |
| SCHEMBL6585 | 0.90 | EPHX1 (0.42) | EPHX1 | |
| SCHEMBL6707 | 0.87 | LPAR1 (0.41) | ALDH1A1THRBHTT | |
| SCHEMBL6660 | 0.86 | SYK (0.41) | SYKMEN1KMT2AALDH1A1THRB | |
| SCHEMBL1679 | 0.85 | EPHX1 (0.39) | EPHX1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7136 | 0.85 | FFAR1 (0.43) | EPHX1THRB | |
| SCHEMBL6870 | 0.82 | SYK (0.40) | EPHX1SYKMEN1KMT2AALDH1A1 | |
| SCHEMBL2285 | 0.82 | LPAR1 (0.41) | EPHX1 | |
| SCHEMBL7741 | 0.79 | CYP4F2 (0.39) | ALDH1A1HPGD | |
| SCHEMBL6869 | 0.78 | SYK (0.41) | SYKMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |