Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Moricizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 0.98 |
| ▸ | MEN1 | O00255 | 3/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.98 |
| ▸ | GAA | P10253 | 2/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | NR1I3 | Q14994 | 4/20 | 0.73 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Moricizine SCHEMBL29599149 | 1.00 | CYP3A4 (1.00) | CYP3A4NR1I2HTR1ACHRM1PDE4D | |
| Moricizine SCHEMBL41358 | 0.99 | LMNA (1.00) | CYP3A4NR1I2HTR1ACHRM1PDE4D | |
| Moricizine SCHEMBL41359 | 0.99 | LMNA (1.00) | CYP3A4NR1I2HTR1ACHRM1PDE4D | |
| Moricizine SCHEMBL9447065 | 0.98 | LMNA (0.98) | CYP3A4NR1I2HTR1ACHRM1PDE4D | |
| Moricizine SCHEMBL1650461 | 0.98 | CYP3A4 (0.97) | CYP3A4NR1I2HTR1ACHRM1PDE4D | |
| SCHEMBL15913933 | 0.89 | CYP3A4 (0.80) | CYP3A4NR1I2HTR1ACHRM1PDE4D | |
| Moricizine SCHEMBL2430390 | 0.88 | CYP3A4 (0.78) | CYP3A4NR1I2HTR1ACHRM1PDE4D | |
| SCHEMBL19225040 | 0.85 | NR1I3 (1.00) | CYP3A4NR1I2HTR1ACHRM1PDE4D | |
| SCHEMBL9446980 | 0.84 | LMNA (0.72) | CYP3A4NR1I2HTR1ACHRM1PDE4D | |
| Moricizine SCHEMBL28086262 | 0.84 | CYP3A4 (0.70) | CYP3A4NR1I2HTR1ACHRM1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4063 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12117453-B2 | Predicting patient response to sodium channel blockers | WASHINGTON UNIVERSITY (US) | 2024-10-15 | — | — | US | claimed |
| EP-3863708-B1 | MIXED IONIC CONDUCTORS AND CORRESPONDING DEVICES, SYSTEMS AND METHODS OF MAKING | BATTELLE MEMORIAL INSTITUTE (US) | 2024-09-11 | — | — | EP | claimed |
| EP-4176841-A1 | PROSTHETIC TISSUE VALVES | Cormatrix Cardiovascular, Inc. (US) | 2023-05-10 | — | — | EP | claimed |
| US-11642419-B2 | Compositions and methods for treating cardiovascular related disorders | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2023-05-09 | — | — | US | claimed |
| EP-2991588-B1 | PROSTHETIC TISSUE VALVES | CORMATRIX CARDIOVASCULAR INC (US) | 2022-10-12 | — | — | EP | claimed |
| EP-3618813-B1 | IMPROVED EXTENDED RELEASE HIGHLY LOADED DRUG COMPOSITIONS | LUBRIZOL ADVANCED MAT INC (US) | 2022-07-06 | — | — | EP | claimed |
| US-11318107-B2 | Pharmaceutical active-containing film delivery device for oral transmucosal administration | Avior, Inc. (US) | 2022-05-03 | — | — | US | claimed |
| US-20210085622-A1 | TRANSMUCOSAL FILM COMPOSITION AND METHODS OF MAKING AND USING THE SAME | Avior, Inc. | 2021-03-25 | — | — | US | claimed |
| US-20210030693-A1 | PHARMACEUTICAL ACTIVE-CONTAINING FILM DELIVERY DEVICE FOR ORAL TRANSMUCOSAL ADMINISTRATION | Avior, Inc. | 2021-02-04 | — | — | US | claimed |
| EP-3768378-A2 | A NOVEL METHOD TO SLOW VENTRICULAR RATE | InCarda Therapeutics, Inc. (US) | 2021-01-27 | — | — | EP | claimed |
| US-6369114-B1 | Administration of an α2-adrenergic receptor agonist to enhance cardiopulmonary resuscitation | INSTITUTE OF CRITICAL CARE MEDICINE | 2002-04-09 | — | — | US | claimed |
| EP-1183011-A1 | METHOD OF TREATING ANGINA AND/OR ANGINAL EQUIVALENTS, AND PHARMACEUTICAL COMPOSITIONS AND KIT RELATED THERETO | Esperion Mergerco, Inc. (US) | 2002-03-06 | — | — | EP | claimed |
| WO-2001092283-A2 | COBALAMIN COMPOUNDS USEFUL AS CARDIOVASCULAR AGENTS AND AS IMAGING AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2001-12-06 | — | — | WO | claimed |
| WO-2001079554-A1 | GENETIC DIAGNOSIS FOR QT PROLONGATION RELATED ADVERSE DRUG REACTIONS | GEORGETOWN UNIVERSITY (US) | 2001-10-25 | — | — | WO | claimed |
| WO-2001039761-A1 | ADMINISTRATION OF AN ALPHA-2 ADRENERGIC RECEPTOR AGONIST TO ENHANCE CARDIOPULMONARY RESUSCITATION | INSTITUTE OF CRITICAL CARE MEDICINE (US) | 2001-06-07 | — | — | WO | claimed |
| EP-1073470-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2001-02-07 | — | — | EP | claimed |
| WO-2000069412-A1 | METHOD OF TREATING ANGINA AND/OR ANGINAL EQUIVALENTS, AND PHARMACEUTICAL COMPOSITIONS AND KIT RELATED THERETO | ESPERION LUV DEVELOPMENT, INC. (US) | 2000-11-23 | — | — | WO | claimed |
| WO-2000048636-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2000-08-24 | — | — | WO | claimed |
| WO-1993010108-A1 | PROCESS FOR THE PREPARATION OF MORICIZINE HYDROCHLORIDE | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-05-27 | — | — | WO | claimed |
| US-5202435-A | Reacting ethanol solution of moricizine with hydrochloric acid at specified molar ratio | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-04-13 | — | — | US | claimed |