Moricizine

Moricizine

SCHEMBL29599149

CCOC(=O)Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1ccccc1S2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A

The experimentally established mechanism targets of Moricizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 1.00
NR1I2 O75469 1/20 1.00
HTR1A P08908 1/20 1.00
CHRM1 P11229 1/20 1.00
PDE4D Q08499 1/20 1.00
KCNH2 Q12809 1/20 1.00
HIF1A Q16665 1/20 1.00
LMNA P02545 7/20 0.98
MEN1 O00255 3/20 0.98
KMT2A Q03164 3/20 0.98
GAA P10253 2/20 0.98
MAPK1 P28482 2/20 0.98
SMN1; SMN2 Q16637 1/20 0.98
CYP2C19 P33261 1/20 0.82
NR1I3 Q14994 4/20 0.73
MAPT P10636 5/20 0.70
TP53 P04637 2/20 0.70
HTT P42858 2/20 0.70
HSD17B10 Q99714 1/20 0.69
USP2 O75604 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Moricizine SCHEMBL16794 1.00 CYP3A4 (1.00) CYP3A4NR1I2HTR1ACHRM1PDE4D
Moricizine SCHEMBL41358 0.99 LMNA (1.00) CYP3A4NR1I2HTR1ACHRM1PDE4D
Moricizine SCHEMBL41359 0.99 LMNA (1.00) CYP3A4NR1I2HTR1ACHRM1PDE4D
Moricizine SCHEMBL9447065 0.98 LMNA (0.98) CYP3A4NR1I2HTR1ACHRM1PDE4D
Moricizine SCHEMBL1650461 0.98 CYP3A4 (0.97) CYP3A4NR1I2HTR1ACHRM1PDE4D
SCHEMBL15913933 0.89 CYP3A4 (0.80) CYP3A4NR1I2HTR1ACHRM1PDE4D
Moricizine SCHEMBL2430390 0.88 CYP3A4 (0.78) CYP3A4NR1I2HTR1ACHRM1PDE4D
SCHEMBL19225040 0.85 NR1I3 (1.00) CYP3A4NR1I2HTR1ACHRM1PDE4D
SCHEMBL9446980 0.84 LMNA (0.72) CYP3A4NR1I2HTR1ACHRM1PDE4D
Moricizine SCHEMBL28086262 0.84 CYP3A4 (0.70) CYP3A4NR1I2HTR1ACHRM1PDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119144639-A Application of heterologous expression Moricin peptide in enhancing insecticidal activity of pathogenic fungi 中国科学院分子植物科学卓越创新中心 2024-12-17 CN claimed
EP-3863708-B1 MIXED IONIC CONDUCTORS AND CORRESPONDING DEVICES, SYSTEMS AND METHODS OF MAKING BATTELLE MEMORIAL INSTITUTE (US) 2024-09-11 EP claimed
EP-4232013-A2 OPIOID-FREE COMPOSITIONS FOR ANESTHESIOLOGICAL APPLICATIONS AND RELATED METHODS AND SYSTEMS Vaporworks Nursing Anesthesia Inc. (US) 2023-08-30 EP claimed
EP-2991588-B1 PROSTHETIC TISSUE VALVES CORMATRIX CARDIOVASCULAR INC (US) 2022-10-12 EP claimed
US-20220218740-A1 OPIOID-FREE COMPOSITIONS FOR ANESTHESIOLOGICAL APPLICATIONS AND RELATED METHODS AND SYSTEMS VAPORWORKS NURSING ANESTHESIA INC. 2022-07-14 US claimed
EP-3618813-B1 IMPROVED EXTENDED RELEASE HIGHLY LOADED DRUG COMPOSITIONS LUBRIZOL ADVANCED MAT INC (US) 2022-07-06 EP claimed
WO-2022084980-A2 OPIOID-FREE COMPOSITIONS FOR ANESTHESIOLOGICAL APPLICATIONS AND RELATED METHODS AND SYSTEMS VAPORWORKS NURSING ANESTHESIA INC. (US) 2022-04-28 WO claimed
WO-2025217305-A1 DEVICES, KITS, AND METHODS FOR DELIVERING MEDICATION VIA THE LUNGS INCARDA THERAPEUTICS, INC. (US) 2025-10-16 WO disclosed
US-12244954-B2 Semiconductor device SAMSUNG ELECTRONICS CO., LTD. (KR) 2025-03-04 US disclosed
EP-4444881-A2 GATA4-TARGETED THERAPEUTICS FOR TREATMENT OF CARDIAC HYPERTROPHY University of Rochester (US) 2024-10-16 EP disclosed
EP-4430187-A2 ANTISENSE OLIGONUCLEOTIDES FOR MODIFYING PROTEIN EXPRESSION University of Rochester (US) 2024-09-18 EP disclosed
EP-4232013-A2 OPIOID-FREE COMPOSITIONS FOR ANESTHESIOLOGICAL APPLICATIONS AND RELATED METHODS AND SYSTEMS Vaporworks Nursing Anesthesia Inc. (US) 2023-08-30 EP disclosed
CN-116515846-A Silkworm cell adhesion protein Pxt1 gene and application 郑州轻工业大学 2023-08-01 CN disclosed
WO-2023086292-A2 GATA4-TARGETED THERAPEUTICS FOR TREATMENT OF CARDIAC HYPERTROPHY UNIVERSITY OF ROCHESTER (US) 2023-05-19 WO disclosed
CN-115997851-A Application of insect antibacterial peptide recombinant protein in preparation of immunopotentiator feed additive for aquaculture 辽宁省海洋水产科学研究院 2023-04-25 CN disclosed
CN-115997851-A Application of insect antibacterial peptide recombinant protein in preparation of immunopotentiator feed additive for aquaculture 辽宁省海洋水产科学研究院 2023-04-25 CN disclosed
CN-110709068-B Improved sustained release high load pharmaceutical compositions 路博润先进材料公司 2022-11-08 CN disclosed
US-20220218740-A1 OPIOID-FREE COMPOSITIONS FOR ANESTHESIOLOGICAL APPLICATIONS AND RELATED METHODS AND SYSTEMS VAPORWORKS NURSING ANESTHESIA INC. 2022-07-14 US disclosed
EP-3618813-B1 IMPROVED EXTENDED RELEASE HIGHLY LOADED DRUG COMPOSITIONS LUBRIZOL ADVANCED MAT INC (US) 2022-07-06 EP disclosed
WO-2022084980-A2 OPIOID-FREE COMPOSITIONS FOR ANESTHESIOLOGICAL APPLICATIONS AND RELATED METHODS AND SYSTEMS VAPORWORKS NURSING ANESTHESIA INC. (US) 2022-04-28 WO disclosed