Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Moricizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.98 |
| ▸ | MEN1 | O00255 | 4/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.98 |
| ▸ | GAA | P10253 | 2/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.97 |
| ▸ | HTR1A | P08908 | 1/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.97 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.97 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | NR1I3 | Q14994 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 5/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Moricizine SCHEMBL41359 | 0.99 | LMNA (1.00) | LMNAMEN1KMT2AGAAMAPK1 | |
| Moricizine SCHEMBL41358 | 0.99 | LMNA (1.00) | LMNAMEN1KMT2AGAAMAPK1 | |
| Moricizine SCHEMBL29599149 | 0.98 | CYP3A4 (1.00) | LMNAMEN1KMT2AGAAMAPK1 | |
| Moricizine SCHEMBL16794 | 0.98 | CYP3A4 (1.00) | LMNAMEN1KMT2AGAAMAPK1 | |
| Moricizine SCHEMBL1650461 | 0.97 | CYP3A4 (0.97) | LMNAMEN1KMT2AGAAMAPK1 | |
| SCHEMBL15913933 | 0.87 | CYP3A4 (0.80) | LMNAMEN1KMT2AGAAMAPK1 | |
| Moricizine SCHEMBL2430390 | 0.87 | CYP3A4 (0.78) | LMNAMEN1KMT2AGAAMAPK1 | |
| SCHEMBL19225040 | 0.83 | NR1I3 (1.00) | LMNAMEN1KMT2AGAAMAPK1 | |
| SCHEMBL9446980 | 0.82 | LMNA (0.72) | LMNAMEN1KMT2AGAAMAPK1 | |
| Moricizine SCHEMBL28086262 | 0.82 | CYP3A4 (0.70) | LMNAMEN1KMT2AGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993010108-A1 | PROCESS FOR THE PREPARATION OF MORICIZINE HYDROCHLORIDE | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-05-27 | — | — | WO | disclosed |
| US-5202435-A | Reacting ethanol solution of moricizine with hydrochloric acid at specified molar ratio | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-04-13 | — | — | US | disclosed |