Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1679533 | 1.00 | LMNA (0.37) | LMNAALOX15BLMPMP22TDP1 | |
| SCHEMBL11031089 | 0.77 | TSHR (0.35) | — | |
| SCHEMBL447741 | 0.74 | PTGS1 (0.36) | — | |
| SCHEMBL447742 | 0.74 | PTGS1 (0.36) | — | |
| Lithium Ion SCHEMBL28788175 | 0.70 | CA4 (0.38) | — | |
| SCHEMBL10803205 | 0.70 | — | — | |
| SCHEMBL9673 | 0.69 | — | — | |
| SCHEMBL15325 | 0.69 | — | — | |
| SCHEMBL5214305 | 0.69 | — | — | |
| SCHEMBL9156223 | 0.69 | ALDH1A1 (0.40) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307189-A1 | SILICONE HYDROGEL CONTACT LENSES WITH CONVERTIBLE COMFORT AGENTS | Novartis AG (CH) | 2011-04-13 | — | — | EP | disclosed |
| EP-2307190-A1 | SILICONE-CONTAINING POLYMERIC MATERALS WITH HYDROLYZABLE GROUPS | Novartis AG (CH) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010011493-A1 | SILICONE-CONTAINING POLYMERIC MATERALS WITH HYDROLYZABLE GROUPS | NOVARTIS AG (CH) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010011492-A1 | SILICONE HYDROGEL CONTACT LENSES WITH CONVERTIBLE COMFORT AGENTS | NOVARTIS AG (CH) | 2010-01-28 | — | — | WO | disclosed |