SCHEMBL16795703

SCHEMBL16795703

Clc1ccc(C(Br)=CBr)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.44
CES1 P23141 3/20 0.44
TSHR P16473 2/20 0.42
MAPK1 P28482 2/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
ALOX15 P16050 1/20 0.42
CYP3A4 P08684 1/20 0.42
ATM Q13315 1/20 0.42
GSK3B P49841 2/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
LMNA P02545 3/20 0.40
CYP2A6 P11509 1/20 0.40
PTGS1 P23219 1/20 0.38
SRD5A2 P31213 1/20 0.38
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
MAPT P10636 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28858460 1.00 CES2 (0.44) CES2CES1TSHRMAPK1L3MBTL1
SCHEMBL16795702 1.00 CES2 (0.44) CES2CES1TSHRMAPK1L3MBTL1
SCHEMBL16634441 0.77 MAPT (0.44) TSHRMAPK1ALOX15CYP3A4CA1
SCHEMBL2011615 0.75 CES2 (0.44) CES2CES1CA1CA2PTGS1
SCHEMBL28472161 0.75 CES2 (0.44) CES2CES1TSHRMAPK1L3MBTL1
SCHEMBL28619042 0.75 CES2 (0.44) CES2CES1TSHRMAPK1L3MBTL1
SCHEMBL5905850 0.74 CES1 (0.39) CES2CES1TSHRMAPK1L3MBTL1
SCHEMBL5905848 0.74 CES1 (0.39) CES2CES1TSHRMAPK1L3MBTL1
SCHEMBL1120634 0.73 PTGS1 (0.50) CES2CES1TSHRMAPK1L3MBTL1
SCHEMBL16795552 0.73 PTGS1 (0.50) CES2CES1TSHRMAPK1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115197046-B Halogenation method of unsaturated hydrocarbon 华南理工大学 2023-12-15 CN disclosed
CN-115197046-A Halogenation method of unsaturated hydrocarbon 华南理工大学 2022-10-18 CN disclosed
WO-2015087094-A1 NEW ARYLALKENYLPROPARGYLAMINE DERIVATIVES EXHIBITING NEUROPROTECTIVE ACTION FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES SEMMELWEIS EGYETEM (HU) 2015-06-18 WO disclosed