Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.50 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10204736 | 0.81 | SMN1; SMN2 (0.45) | ERCC5FEN1 | |
| SCHEMBL38664634 | 0.81 | KMO (0.48) | KMOPRSS1PRSS2PRSS3ERCC5 | |
| SCHEMBL93850 | 0.80 | MAOA (0.54) | — | |
| SCHEMBL13442275 | 0.79 | KMO (0.59) | KMOPRSS1PRSS2PRSS3ERCC5 | |
| SCHEMBL16795663 | 0.77 | PRSS1 (0.56) | PRSS1PRSS2PRSS3 | |
| SCHEMBL2070299 | 0.76 | ERCC5 (0.66) | KMOPRSS1PRSS2PRSS3ERCC5 | |
| SCHEMBL20243662 | 0.75 | PRSS1 (0.64) | KMOPRSS1PRSS2PRSS3ERCC5 | |
| SCHEMBL2135450 | 0.75 | KMO (0.55) | KMOPRSS1PRSS2PRSS3ERCC5 | |
| SCHEMBL26828809 | 0.74 | PRSS1 (0.49) | KMOPRSS1PRSS2PRSS3ERCC5 | |
| SCHEMBL28604413 | 0.73 | PARP1 (0.48) | ERCC5FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015087094-A1 | NEW ARYLALKENYLPROPARGYLAMINE DERIVATIVES EXHIBITING NEUROPROTECTIVE ACTION FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SEMMELWEIS EGYETEM (HU) | 2015-06-18 | — | — | WO | disclosed |
| CN-1040321-C | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses | UPJOHN CO (US) | 1998-10-21 | — | — | CN | disclosed |
| CN-1090279-A | Be used for the treatment of HIV and other retroviral pyran-2-ones and 5,6-dihydropyrane-2-ketone | UPJOHN CO (US) | 1994-08-03 | — | — | CN | disclosed |