Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.46 |
| ▸ | TUBB | P07437 | 2/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.46 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12772157 | 0.79 | KMT2A (0.60) | KMT2AMAPTMEN1LMNACYP1A2 | |
| SCHEMBL8862695 | 0.76 | HTR1A (0.49) | KMT2AMAPTMEN1GAAALDH1A1 | |
| SCHEMBL1616051 | 0.75 | TSHR (0.50) | MAPTCYP3A4TUBB4ATUBBTUBA3C | |
| SCHEMBL16797057 | 0.74 | NPC1 (0.45) | KMT2AMAPTMEN1GAAALDH1A1 | |
| SCHEMBL3629871 | 0.73 | NPC1 (0.59) | KMT2AMAPTMEN1LMNACYP1A2 | |
| SCHEMBL5205439 | 0.73 | TNFRSF1A (0.51) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL16800856 | 0.73 | SCN8A (0.49) | LMNAAPPALDH1A1TDP1MAOB | |
| SCHEMBL3237857 | 0.72 | MAOB (0.55) | MAPTALDH1A1TNFRSF1ATHRBMAOB | |
| SCHEMBL3631073 | 0.72 | TUBB4A (0.50) | KMT2AMAPTMEN1LMNACYP1A2 | |
| SCHEMBL18397169 | 0.72 | ALDH1A1 (0.54) | KMT2AMAPTMEN1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080108-A1 | TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015089139-A1 | TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2015-06-18 | — | — | WO | disclosed |