Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 2/20 | 0.47 |
| ▸ | FNTB | P49356 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23453723 | 0.77 | AR (0.44) | ELANE | |
| SCHEMBL16797299 | 0.77 | CHEK1 (0.42) | FNTAFNTBELANEKDM4EPOLB | |
| SCHEMBL5937220 | 0.76 | ALPL (0.70) | POLBALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL14705880 | 0.76 | ELANE (0.46) | FNTAFNTBELANEKDM4EALDH1A1 | |
| SCHEMBL23453724 | 0.75 | DHODH (0.48) | FNTAFNTBELANEKDM4EPOLB | |
| SCHEMBL7460449 | 0.73 | PDE4D (0.52) | FNTAFNTBELANEKDM4EPOLB | |
| SCHEMBL5937229 | 0.73 | ALDH1A1 (0.53) | FNTAFNTBELANEKDM4EALDH1A1 | |
| SCHEMBL492345 | 0.73 | KDM4E (0.61) | ELANEKDM4EPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL6466270 | 0.73 | AR (0.63) | FNTAFNTBKDM4EPOLBALDH1A1 | |
| SCHEMBL2997892 | 0.72 | CA12 (0.56) | FNTAFNTBELANEKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080100-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | Celgene Quanticel Research, Inc. (US) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015089192-A1 | INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1 | Quanticel Pharmaceuticals, Inc. (US) | 2015-06-18 | — | — | WO | disclosed |