Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16798376 | 0.86 | KDR (0.34) | MEN1ALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL16798098 | 0.84 | RECQL (0.35) | ALDH1A1SMN1; SMN2KDR | |
| SCHEMBL16798101 | 0.84 | BTK (0.34) | BTKKDR | |
| SCHEMBL16798103 | 0.82 | CKS1B (0.37) | KDR | |
| SCHEMBL16798100 | 0.77 | HTR7 (0.35) | BTKALDH1A1LMNAKDR | |
| SCHEMBL16798368 | 0.73 | KDR (0.34) | BTKKDR | |
| SCHEMBL16766383 | 0.69 | BTK (0.54) | BTKMEN1MITFALDH1A1LMNA | |
| SCHEMBL19743711 | 0.62 | HTR1A (0.44) | MEN1ALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL19743714 | 0.59 | ALDH1A1 (0.46) | ALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL28672326 | 0.58 | CKS1B (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077384-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY | F. Hoffmann-La Roche AG (CH) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015082583-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-11 | — | — | WO | disclosed |