Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 9/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | MLYCD | O95822 | 1/20 | 0.44 |
| ▸ | RORA | P35398 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728267 | 0.86 | HDAC1 (0.53) | SMN1; SMN2HDAC1HDAC6CA1CA2 | |
| SCHEMBL31434967 | 0.85 | CYP1A2 (0.56) | SMN1; SMN2HDAC1HDAC6CA1CA2 | |
| SCHEMBL9185909 | 0.85 | CYP1A2 (0.56) | SMN1; SMN2HDAC1HDAC6CA1CA2 | |
| SCHEMBL2080632 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2CA1CA2CA9MEN1 | |
| SCHEMBL5524582 | 0.82 | HDAC1 (0.55) | SMN1; SMN2HDAC1HDAC6CA1CA2 | |
| SCHEMBL29739646 | 0.82 | HDAC1 (0.55) | SMN1; SMN2HDAC1HDAC6CA1CA2 | |
| SCHEMBL27563485 | 0.77 | HDAC1 (0.50) | SMN1; SMN2HDAC1HDAC6CA1CA2 | |
| SCHEMBL18151514 | 0.76 | RORC (0.72) | CA1CA2CA9RORCRORA | |
| SCHEMBL29809375 | 0.75 | HDAC1 (0.63) | SMN1; SMN2HDAC1HDAC6CA1CA2 | |
| SCHEMBL3472841 | 0.75 | HDAC1 (0.63) | SMN1; SMN2HDAC1HDAC6CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077372-A1 | ROR GAMMA (RORY) MODULATORS | Lead Pharma Cel Models IP B.V. (NL) | 2016-10-12 | — | — | EP | claimed |
| WO-2015082533-A1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2015-06-11 | — | — | WO | claimed |