SCHEMBL3472841

SCHEMBL3472841

CC(=O)Nc1ccc(Br)cc1F

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.63
HDAC6 Q9UBN7 1/20 0.63
LMNA P02545 5/20 0.59
ALDH1A1 P00352 4/20 0.59
NPC1 O15118 3/20 0.59
RAB9A P51151 3/20 0.59
SMN1; SMN2 Q16637 3/20 0.59
CA1 P00915 2/20 0.57
CA2 P00918 2/20 0.57
CA9 Q16790 2/20 0.57
L3MBTL1 Q9Y468 3/20 0.55
GRK2 P25098 1/20 0.55
RECQL P46063 1/20 0.55
CTDSP1 Q9GZU7 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
MAPT P10636 3/20 0.54
HTT P42858 3/20 0.54
GAA P10253 2/20 0.54
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29809375 1.00 HDAC1 (0.63) HDAC1HDAC6LMNAALDH1A1NPC1
SCHEMBL410860 0.86 LMNA (0.56) LMNAALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL4796769 0.85 ALDH1A1 (0.54) HDAC1HDAC6LMNAALDH1A1NPC1
SCHEMBL2491853 0.83 LMNA (0.66) LMNAALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL1284518 0.82 ALDH1A1 (0.64) HDAC1HDAC6LMNAALDH1A1NPC1
SCHEMBL28618912 0.82 ALDH1A1 (0.59) LMNAALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL2708564 0.81 ALDH1A1 (0.58) HDAC1HDAC6ALDH1A1NPC1RAB9A
SCHEMBL20560335 0.81 NPC1 (0.59) LMNAALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL31068310 0.81 KIF11 (0.66) LMNAALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL5428786 0.81 KIF11 (0.66) LMNAALDH1A1NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114544785-B Flurbiprofen and detection method of impurities thereof 远大生命科学(鞍山)有限公司 2024-06-21 CN claimed
CN-114544785-A Method for detecting flurbiprofen and impurities thereof 远大生命科学(辽宁)有限公司 2022-05-27 CN claimed
CN-114047216-A Sorafenib tosylate content determination method based on nuclear magnetic resonance quantification technology 北京绿谱科技有限公司 2022-02-15 CN claimed
US-20250179059-A1 ANTICANCER COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2025-06-05 US disclosed
US-20250026766-A1 Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors BEIGENE, LTD. (KY) 2025-01-23 US disclosed
US-12162870-B2 Anticancer compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-12-10 US disclosed
US-20240327386-A1 AHR INHIBITOR, USE THEREOF, AND PREPARATION METHOD THEREFOR CHONGQING PHARSCIN INNOBIO CO., LTD. (CN) 2024-10-03 US disclosed
CN-114544785-B Flurbiprofen and detection method of impurities thereof 远大生命科学(鞍山)有限公司 2024-06-21 CN disclosed
EP-4351560-A1 ANTICANCER COMPOUNDS The Regents of the University of California (US) 2024-04-17 EP disclosed
CN-117794525-A Anticancer compounds 加利福尼亚大学董事会 2024-03-29 CN disclosed
CN-117705852-A Method for measuring ethyl 2- (4-bromo-3-fluorophenyl) acetate content by nuclear magnetic resonance fluorine spectrum 南京药石科技股份有限公司 2024-03-15 CN disclosed
EP-0778264-A1 Tertiary amines having antimycotic and cholesterol lowering activity F. HOFFMANN-LA ROCHE AG (CH) 1997-06-11 EP disclosed
US-5539112-A 5-aminoflavone derivatives KYOWA HAKKO KOGYO CO., LTD. (JP) 1996-07-23 US disclosed
EP-0638566-A1 5-Aminoflavone derivatives, their preparation and their use as antibacterial, anti-estrogenic and/or antitumor agent KYOWA HAKKO KOGYO CO., LTD. (JP) 1995-02-15 EP disclosed
US-5164502-A Fluorinating agents DOWELANCO (US) 1992-11-17 US disclosed
US-5116982-A Fluorination DOWELANCO (US) 1992-05-26 US disclosed
EP-0470669-A2 Preparation of fluorophenols, fluorohalophenols, N-acylfluoroanilines, and N-acylfluorohaloanilines DOWELANCO (US) 1992-02-12 EP disclosed
US-4801408-A 3-AMINO-4-FLUORO-6-HALOPHENYLTHIOACETIC ACIDS, 5-SUBSTITUTED ACETANILIDES, HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1989-01-31 US disclosed
US-4709049-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-11-24 US disclosed
US-4684397-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-08-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179059-A1 ANTICANCER COMPOUNDS BET1, BRD4, BICRA HDAC1 122/4885HDAC6 216/4885LMNA 4337/4885
US-20240327386-A1 AHR INHIBITOR, USE THEREOF, AND PREPARATION METHOD THEREFOR AHR, ARNT, AIPL1 HDAC1 1321/4885HDAC6 1066/4885LMNA 3754/4885
US-20250026766-A1 Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors POLQ, POLK, POLI HDAC1 219/4885HDAC6 495/4885LMNA 2654/4885
US-12162870-B2 Anticancer compounds BET1, BRD4, BICRA HDAC1 122/4885HDAC6 216/4885LMNA 4337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.