Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.53 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23647680 | 0.85 | SMN1; SMN2 (0.59) | HPGDSMN1; SMN2LMNAHTTCYP4F2 | |
| SCHEMBL1421898 | 0.83 | HPGD (0.65) | HPGDSMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL4161796 | 0.81 | HPGD (0.62) | HPGDSMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL4113212 | 0.80 | CYP4F2 (0.76) | HPGDSMN1; SMN2LMNAHTTCYP4F2 | |
| SCHEMBL11560978 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNACYP4F2CYP4A11MAPT | |
| SCHEMBL398078 | 0.78 | HPGD (0.57) | HPGDSMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL12255153 | 0.77 | LMNA (0.58) | HPGDSMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL2693160 | 0.77 | ALDH1A1 (0.63) | HPGDSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL2286242 | 0.77 | CYP4F2 (0.61) | HPGDSMN1; SMN2LMNACYP4F2CYP4A11 | |
| SCHEMBL12309811 | 0.76 | HPGD (0.77) | HPGDSMN1; SMN2LMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015083130-A1 | FUSED PYRIDINE AND PYRIMIDINE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-06-11 | — | — | WO | disclosed |
| WO-2015083130-A1 | FUSED PYRIDINE AND PYRIMIDINE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-06-11 | — | — | WO | disclosed |