Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099525 | 0.92 | SMN1; SMN2 (0.53) | SMN1; SMN2KIF11PDE10AALDH1A1MEN1 | |
| SCHEMBL13858152 | 0.90 | KIF11 (0.47) | SMN1; SMN2KIF11ALDH1A1MEN1KMT2A | |
| SCHEMBL18999755 | 0.76 | KIF11 (0.44) | SMN1; SMN2KIF11PDE10AALDH1A1MEN1 | |
| SCHEMBL5351652 | 0.73 | ALDH1A1 (0.48) | SMN1; SMN2KIF11PDE10AALDH1A1MEN1 | |
| SCHEMBL2994229 | 0.73 | ALDH1A1 (0.48) | SMN1; SMN2KIF11PDE10AALDH1A1MEN1 | |
| SCHEMBL24719100 | 0.73 | MEN1 (0.58) | SMN1; SMN2MEN1KMT2AMAPK1HSD17B10 | |
| SCHEMBL29938143 | 0.73 | ALDH1A1 (0.48) | SMN1; SMN2KIF11PDE10AALDH1A1MEN1 | |
| SCHEMBL12724450 | 0.73 | SMN1; SMN2 (0.52) | SMN1; SMN2KIF11ALDH1A1MEN1KMT2A | |
| SCHEMBL1333739 | 0.73 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9198448 | 0.73 | ALDH1A1 (0.48) | SMN1; SMN2KIF11PDE10AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077372-A1 | ROR GAMMA (RORY) MODULATORS | Lead Pharma Cel Models IP B.V. (NL) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015082533-A1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2015-06-11 | — | — | WO | disclosed |