Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PEPD | P12955 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16800190 | 1.00 | PEPD (0.39) | PEPDFKBP1AMEN1KMT2AHDAC8 | |
| SCHEMBL16541366 | 1.00 | PEPD (0.39) | PEPDFKBP1AMEN1KMT2AHDAC8 | |
| SCHEMBL30753312 | 0.95 | FKBP1A (0.38) | PEPDFKBP1AMEN1KMT2AHDAC8 | |
| SCHEMBL29524116 | 0.95 | FKBP1A (0.38) | PEPDFKBP1AMEN1KMT2AHDAC8 | |
| SCHEMBL25333165 | 0.94 | PEPD (0.38) | PEPDFKBP1AMEN1KMT2AHDAC8 | |
| SCHEMBL24020778 | 0.94 | FKBP1A (0.38) | PEPDFKBP1AMEN1KMT2AHDAC8 | |
| SCHEMBL16555307 | 0.91 | FKBP1A (0.34) | PEPDFKBP1AMEN1KMT2AHDAC8 | |
| SCHEMBL16555309 | 0.91 | FKBP1A (0.34) | PEPDFKBP1AMEN1KMT2AHDAC8 | |
| SCHEMBL29780441 | 0.91 | FKBP1A (0.36) | PEPDFKBP1AMEN1KMT2AHDAC8 | |
| SCHEMBL22150847 | 0.90 | NFKB1 (0.36) | PEPDFKBP1AMEN1KMT2AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9718807-B2 | Synthesis of antiviral compound | GILEAD PHARMASSET LLC (US) | 2017-08-01 | — | — | US | disclosed |
| US-9718807-B2 | Synthesis of antiviral compound | GILEAD PHARMASSET LLC (US) | 2017-08-01 | — | — | US | disclosed |
| US-20160340345-A1 | SYNTHESIS OF ANTIVIRAL COMPOUND | GILEAD SCIENCES, INC. | 2016-11-24 | — | — | US | disclosed |
| US-20160340345-A1 | SYNTHESIS OF ANTIVIRAL COMPOUND | GILEAD SCIENCES, INC. | 2016-11-24 | — | — | US | disclosed |
| EP-2855454-B1 | SYNTHESIS OF ANTIVIRAL COMPOUND | GILEAD PHARMASSET LLC (US) | 2016-05-25 | — | — | EP | disclosed |
| US-20150232453-A1 | SYNTHESIS OF ANTIVIRAL COMPOUND | GILEAD PHARMASSET LLC | 2015-08-20 | — | — | US | disclosed |
| US-20150232453-A1 | SYNTHESIS OF ANTIVIRAL COMPOUND | GILEAD PHARMASSET LLC | 2015-08-20 | — | — | US | disclosed |
| US-9056860-B2 | Synthesis of antiviral compound | GILEAD PHARMASSET LLC (US) | 2015-06-16 | — | — | US | disclosed |
| US-9056860-B2 | Synthesis of antiviral compound | GILEAD PHARMASSET LLC (US) | 2015-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232453-A1 | SYNTHESIS OF ANTIVIRAL COMPOUND | EIF2AK2, MAVS, SARS1 | PEPD 1783/4885FKBP1A 2740/4885MEN1 3312/4885 |
| US-20160340345-A1 | SYNTHESIS OF ANTIVIRAL COMPOUND | EIF2AK2, MAVS, SARS1 | PEPD 1783/4885FKBP1A 2740/4885MEN1 3312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.