Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | AHR | P35869 | 2/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.40 |
| ▸ | PRKDC | P78527 | 3/20 | 0.39 |
| ▸ | CDC14B | O60729 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16801111 | 0.90 | CYP1A2 (0.41) | CYP1A2ALDH1A1HPGDHSD17B10THRB | |
| SCHEMBL16801053 | 0.90 | CYP1A2 (0.44) | CYP1A2ALDH1A1HPGDHSD17B10THRB | |
| SCHEMBL16801202 | 0.87 | CYP1A2 (0.39) | CYP1A2ALDH1A1HPGDHSD17B10THRB | |
| SCHEMBL16801018 | 0.85 | ALDH1A1 (0.45) | CYP1A2ALDH1A1HPGDHSD17B10THRB | |
| SCHEMBL18159587 | 0.84 | ALDH1A1 (0.40) | CYP1A2ALDH1A1HPGDHSD17B10THRB | |
| SCHEMBL16801416 | 0.83 | ALDH1A1 (0.48) | CYP1A2ALDH1A1HPGDHSD17B10THRB | |
| SCHEMBL16801117 | 0.83 | CYP19A1 (0.36) | CYP1A2ALDH1A1HPGDHSD17B10THRB | |
| SCHEMBL12698548 | 0.82 | CTRC (0.42) | CYP1A2ALDH1A1HPGDHSD17B10THRB | |
| SCHEMBL27013127 | 0.81 | CYP1A2 (0.40) | CYP1A2ALDH1A1HPGDHSD17B10THRB | |
| SCHEMBL18159581 | 0.81 | PRKDC (0.34) | CYP1A2ALDH1A1HPGDHSD17B10THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11917913-B2 | Substituted oxepines | MERCK PATENT GMBH (DE) | 2024-02-27 | — | — | US | disclosed |
| US-11917913-B2 | Substituted oxepines | MERCK PATENT GMBH (DE) | 2024-02-27 | — | — | US | disclosed |
| US-20190280218-A1 | SUBSTITUTED OXEPINES | MERCK PATENT GMBH (DE) | 2019-09-12 | — | — | US | disclosed |
| US-10374170-B2 | Substituted oxepines | MERCK PATENT GMBH (DE) | 2019-08-06 | — | — | US | disclosed |
| US-20160308146-A1 | SUBSTITUTED OXEPINES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | US | disclosed |
| WO-2015082046-A2 | SUBSTITUTED OXEPINES | MERCK PATENT GMBH (DE) | 2015-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11917913-B2 | Substituted oxepines | OXGR1, OXTR, OCIAD2 | CYP1A2 885/4885ALDH1A1 1740/4885HPGD 907/4885 |
| US-10374170-B2 | Substituted oxepines | OXGR1, OXTR, OCIAD2 | CYP1A2 885/4885ALDH1A1 1740/4885HPGD 907/4885 |
| US-20190280218-A1 | SUBSTITUTED OXEPINES | OXGR1, OXTR, OCIAD2 | CYP1A2 885/4885ALDH1A1 1740/4885HPGD 907/4885 |
| US-20160308146-A1 | SUBSTITUTED OXEPINES | OXGR1, OXTR, OCIAD2 | CYP1A2 885/4885ALDH1A1 1740/4885HPGD 907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.