Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16801481 | 0.88 | ALOX15 (1.00) | ALOX15MAPTNPSR1EPHX2ALDH1A1 | |
| SCHEMBL30037475 | 0.88 | ALOX15 (1.00) | ALOX15MAPTNPSR1EPHX2ALDH1A1 | |
| SCHEMBL16801352 | 0.88 | ALOX15 (0.71) | ALOX15MAPTNPSR1EPHX2ALDH1A1 | |
| SCHEMBL15320704 | 0.88 | ALOX15 (0.71) | ALOX15MAPTNPSR1EPHX2ALDH1A1 | |
| SCHEMBL27218065 | 0.85 | ALOX15 (0.67) | ALOX15MAPTEPHX2ALDH1A1HPGD | |
| SCHEMBL23096818 | 0.81 | ALOX15 (0.62) | ALOX15MAPTNPSR1EPHX2ALDH1A1 | |
| SCHEMBL18134961 | 0.80 | ALOX15 (0.53) | ALOX15MAPTNPSR1EPHX2ALDH1A1 | |
| SCHEMBL21996630 | 0.78 | ALOX15 (0.83) | ALOX15MAPTNPSR1EPHX2ALDH1A1 | |
| SCHEMBL30792860 | 0.78 | ALOX15 (0.83) | ALOX15MAPTNPSR1EPHX2ALDH1A1 | |
| SCHEMBL24956407 | 0.75 | ALOX15 (0.47) | ALOX15MAPTNPSR1EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160297748-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2016-10-13 | — | — | US | disclosed |
| WO-2015084749-A1 | MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297748-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | AIFM2, GPX1, GPX4 | ALOX15 92/4885MAPT 171/4885NPSR1 1251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.