SCHEMBL1680253

SCHEMBL1680253

COc1ccc2c(c1)c(C1=C(c3c[nH]c4ccccc34)C(=O)NC1=O)cn2CCCN(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKD1 Q15139 2/20 1.00
TDP1 Q9NUW8 2/20 1.00
PRKACA P17612 10/20 0.78
PRKACG P22612 10/20 0.78
PRKACB P22694 10/20 0.78
GSK3B P49841 5/20 0.78
CDK4 P11802 3/20 0.78
CCND1 P24385 3/20 0.78
PRKCA P17252 3/20 0.78
CCNB2 O95067 3/20 0.78
CDK1 P06493 3/20 0.78
CCNB1 P14635 3/20 0.78
CCNB3 Q8WWL7 3/20 0.78
PIM1 P11309 2/20 0.78
PRKCB P05771 2/20 0.78
PRKCH P24723 2/20 0.78
PRKCQ Q04759 2/20 0.78
PRKCD Q05655 2/20 0.78
MEN1 O00255 1/20 0.78
PRKD3 O94806 1/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29525501 1.00 PRKD1 (1.00) PRKD1TDP1PRKACAPRKACGPRKACB
SCHEMBL29353099 1.00 PRKD1 (1.00) PRKD1TDP1PRKACAPRKACGPRKACB
SCHEMBL29041083 0.96 PRKD1 (0.92) PRKD1TDP1PRKACAPRKACGPRKACB
SCHEMBL9085119 0.95 PRKD1 (0.90) PRKD1TDP1PRKACAPRKACGPRKACB
SCHEMBL7814801 0.94 PRKD1 (0.88) PRKD1TDP1PRKACAPRKACGPRKACB
SCHEMBL7823817 0.93 PRKD1 (0.87) PRKD1TDP1PRKACAPRKACGPRKACB
SCHEMBL9086159 0.93 PRKD1 (0.87) PRKD1TDP1PRKACAPRKACGPRKACB
SCHEMBL7815373 0.91 PRKD1 (0.84) PRKD1TDP1PRKACAPRKACGPRKACB
SCHEMBL9085659 0.89 PRKD1 (0.81) PRKD1TDP1PRKACAPRKACGPRKACB
SCHEMBL9083990 0.89 PRKD1 (0.81) PRKD1TDP1PRKACAPRKACGPRKACB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230201173-A1 SMAD4 Complex Inducers and Uses in Cancer Therapy UNIV EMORY (US) 2023-06-29 US claimed
US-20120238019-A1 STEM CELL CULTURE MEDIA FOR MAINTAINING STEMNESS OR INDUCING DIFFERENTIATION OF STEM CELLS COLLEGE OF MEDICINE POCHON CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) 2012-09-20 US claimed
EP-0397060-B1 Maleinimide derivatives and their use as medicines GOEDECKE AG (DE) 2001-11-21 EP claimed
US-5380746-A Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them GOEDECKE AKTIENGESELLSCHAFT (DE) 1995-01-10 US claimed
EP-0397060-A2 Maleinimide derivatives and their use as medicines GÖDECKE AKTIENGESELLSCHAFT (DE) 1990-11-14 EP claimed
US-20260049275-A1 INDUCED STEM CELLS UNIV MONASH (AU) 2026-02-19 US disclosed
EP-4678737-A1 METHOD FOR PRODUCING PRIMED PLURIPOTENT STEM CELLS Kyoto University (JP) 2026-01-14 EP disclosed
US-12492372-B2 Induced stem cells MONASH UNIVERSITY (AU) 2025-12-09 US disclosed
US-20250290034-A1 METHOD FOR PRODUCING NAÏVE PLURIPOTENT STEM CELLS KYOTO UNIVERSITY (JP) 2025-09-18 US disclosed
US-12385008-B2 Method for producing retinal tissue Sumitomo Pharma Co., Ltd. (JP) 2025-08-12 US disclosed
EP-4582534-A1 METHOD FOR PRODUCING NAÏVE PLURIPOTENT STEM CELLS Kyoto University (JP) 2025-07-09 EP disclosed
US-20250145965-A1 PRODUCTION METHOD FOR INDUCED PLURIPOTENT STEM CELLS RIKEN (JP) 2025-05-08 US disclosed
WO-2009029678-A1 PROTEIN KINASE C-δ INHIBITORS THAT PROTECT AGAINST CELLULAR INJURY AND INFLAMMATION AND PROMOTE ASTROCYTE PROLIFERATION KAI PHARMACEUTICALS, INC. (US) 2009-03-05 WO disclosed
WO-2008109382-A1 NUCLEIC ACID COMPOUNDS FOR INHIBITING PKN3 GENE EXPRESSION AND USES THEREOF MDRNA, INC. (US) 2008-09-12 WO disclosed
WO-2008089494-A2 METHODS OF USE OF EPSILON INHIBITOR COMPOUNDS FOR THE ATTENUATION OF PAIN KAI PHARMACEUTICALS, INC. (US) 2008-07-24 WO disclosed
US-20080103086-A1 METHODS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH THE SECRETION OF HMGB1 INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) 2008-05-01 US disclosed
EP-0397060-B1 Maleinimide derivatives and their use as medicines GOEDECKE AG (DE) 2001-11-21 EP disclosed
US-5516915-A Bis-(1H-indol-3-yl)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them GOEDECKE AKTIENGESELLSCHAFT (DE) 1996-05-14 US disclosed
US-5380746-A Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them GOEDECKE AKTIENGESELLSCHAFT (DE) 1995-01-10 US disclosed
EP-0397060-A2 Maleinimide derivatives and their use as medicines GÖDECKE AKTIENGESELLSCHAFT (DE) 1990-11-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260049275-A1 INDUCED STEM CELLS SALL4, SOX18, LEF1 PRKD1 570/4885TDP1 2968/4885PRKACA 1458/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.