SCHEMBL1680381

SCHEMBL1680381

c1ccc(Oc2ccncc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 8/20 0.67
TSHR P16473 1/20 0.67
NR1H2 P55055 1/20 0.50
BAX Q07812 1/20 0.50
MAOA P21397 1/20 0.50
NOTUM Q6P988 1/20 0.50
LMNA P02545 2/20 0.47
CYP3A4 P08684 1/20 0.47
HTT P42858 1/20 0.47
MMP13 P45452 1/20 0.47
MAPK14 Q16539 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
NPC1 O15118 1/20 0.45
SCN4A P35499 1/20 0.45
RAB9A P51151 1/20 0.45
MAOB P27338 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
SLC6A2 P23975 1/20 0.44
SLC6A4 P31645 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30047550 0.97 LTA4H (0.63) LTA4HTSHRNR1H2BAXMAOA
Ammonia Solution, Strong SCHEMBL3454484 0.97 LTA4H (0.63) LTA4HTSHRNR1H2BAXMAOA
Diphenylether SCHEMBL28242079 0.90 NOTUM (0.67) LTA4HTSHRNR1H2BAXMAOA
Diphenylether SCHEMBL27977199 0.89 LTA4H (0.67) LTA4HTSHRNR1H2BAXMAOA
SCHEMBL8540552 0.88 LMNA (0.47) LTA4HTSHRNOTUMLMNACYP3A4
SCHEMBL6512870 0.87 LTA4H (0.50) LTA4HTSHRLMNACYP3A4HTT
SCHEMBL7011494 0.85 NOTUM (0.61) LTA4HTSHRNR1H2BAXMAOA
Diphenylether SCHEMBL8462019 0.82 LTA4H (0.86) LTA4HTSHRNR1H2BAXMAOA
Diphenylether SCHEMBL8157951 0.82 LTA4H (0.86) LTA4HTSHRNR1H2BAXMAOA
Diphenylether SCHEMBL11437632 0.82 LTA4H (0.86) LTA4HTSHRNR1H2BAXMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 224 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112876457-A Novel 4-phenoxypyridine derivative and application thereof 辽宁大学 2021-06-01 CN claimed
CN-108329258-B Semicarbazone structure-containing 4-phenoxypyridine derivative and application thereof 辽宁大学 2021-04-13 CN claimed
CN-111303121-A 4-phenoxypyridine compound containing quinoxalinone and application thereof 辽宁大学 2020-06-19 CN claimed
CN-110684013-A 4-phenoxypyridine derivatives containing 3-pyridazinone, 4-pyridazinone and 1,2, 4-triazinone structures and application thereof 辽宁大学 2020-01-14 CN claimed
CN-110590291-A Method for repairing cracking of house wall 广东穗都建筑工程有限公司 2019-12-20 CN claimed
CN-110528490-A Treatment Methods of Soft Ground GUANGZHOU MINGHUI CONSTRUCTION ENG CO LTD 2019-12-03 CN claimed
CN-110218205-A Pyridine structure contained 2,4- diarylamino pyridine derivatives and its application 辽宁大学 2019-09-10 CN claimed
CN-109096250-A 4- phenoxypyridines class compound and its application containing pyridazinone 辽宁大学 2018-12-28 CN claimed
CN-108329258-A The 4- phenoxypyridines analog derivatives of the structure containing semicarbazones and its application 辽宁大学 2018-07-27 CN claimed
CN-103087054-B 4-pyridine phenyl ether compounds and preparation method thereof and application SHANDONG UNIVERSITY (CN) 2015-12-23 CN claimed
CN-103087054-A 4-pyridyl phenyl ether compounds, and preparation method and application thereof UNIV SHANDONG 2013-05-08 CN claimed
US-20100174089-A1 HETEROARYL ARYL ETHERS SALTIGO GMBH (DE) 2010-07-08 US claimed
EP-2179989-A2 Process for the preparation of heteroaryl - aryl ether Saltigo GmbH (DE) 2010-04-28 EP claimed
CN-1021815-C Process for the preparation of diesters of adipic acid SHELL INT RESEARCH (NL) 1993-08-18 CN claimed
EP-0284170-B1 PROCESS FOR THE PREPARATION OF A DIESTER OF ADIPIC ACID SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1991-10-16 EP claimed
US-5015680-A Production of a thermoplastically processable, aromatic polyamide using a 4-phenoxypyridine stabilizer HUELS AKTIENGESELLSCHAFT (DE) 1991-05-14 US claimed
EP-0384981-A1 Process for manufacture of a thermoplastic, aromatic and processable polyamide HÜLS AKTIENGESELLSCHAFT (DE) 1990-09-05 EP claimed
US-4861912-A Process for the preparation of a diester of adipic acid SHELL OIL COMPANY (US) 1989-08-29 US claimed
CN-88101605-A Process for preparing adipic diester 1988-11-23 CN claimed
EP-0284170-A1 Process for the preparation of a diester of adipic acid SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1988-09-28 EP claimed