SCHEMBL8540552

SCHEMBL8540552

c1cc(Oc2ccncc2)ccn1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.47
MAPT P10636 2/20 0.47
LTA4H P09960 2/20 0.45
TSHR P16473 3/20 0.44
MMP1 P03956 4/20 0.42
SCN9A Q15858 1/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
ALDH1A1 P00352 2/20 0.42
HDAC8 Q9BY41 1/20 0.42
CYP2D6 P10635 1/20 0.42
CHRM1 P11229 1/20 0.42
MAPK1 P28482 1/20 0.42
KCNA1 Q09470 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
TDP1 Q9NUW8 2/20 0.40
CYP3A4 P08684 1/20 0.40
CTSD P07339 1/20 0.40
DDAH1 O94760 1/20 0.40
NOS1 P29475 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22061918 0.91 LMNA (0.44) LMNAMAPTLTA4HTSHRMMP1
SCHEMBL1680381 0.88 LTA4H (0.67) LMNAMAPTLTA4HTSHRKMT2A
Ammonia Solution, Strong SCHEMBL3454484 0.86 LTA4H (0.63) LMNAMAPTLTA4HTSHRKMT2A
SCHEMBL30047550 0.86 LTA4H (0.63) LMNALTA4HTSHRSMN1; SMN2CYP3A4
SCHEMBL2763353 0.84 NPC1 (0.59) LMNALTA4HMEN1KMT2AALDH1A1
SCHEMBL3446721 0.84 LTA4H (0.42) LMNAMAPTLTA4HTSHRMMP1
SCHEMBL15226636 0.84 MAPT (0.56) LMNAMAPTLTA4HMMP1SCN9A
SCHEMBL11487476 0.84 MAOA (0.56) LTA4HSCN9ACYP3A4
SCHEMBL12260957 0.84 LTA4H (0.42) LMNAMAPTLTA4HTSHRMMP1
SCHEMBL6690582 0.84 LTA4H (0.42) LMNAMAPTLTA4HTSHRMMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119331134-A Catalyst component for olefin polymerization, catalyst for olefin polymerization and application of catalyst component 中国石油天然气股份有限公司 2025-01-21 CN claimed
CN-111303150-A High-efficiency narrow-half-peak-width aggregation state luminescent material 苏州大学 2020-06-19 CN claimed
CN-119331134-A Catalyst component for olefin polymerization, catalyst for olefin polymerization and application of catalyst component 中国石油天然气股份有限公司 2025-01-21 CN disclosed
CN-119331131-A Polymerization catalyst component of olefin, polymerization catalyst of olefin and application of polymerization catalyst component 中国石油天然气股份有限公司 2025-01-21 CN disclosed
CN-116462709-A Phosphate group-containing compound, preparation method thereof and application thereof in perovskite light-emitting device 中国科学院长春应用化学研究所 2023-07-21 CN disclosed
US-11548875-B2 Inhibitor compounds for male contraception UNIVERSITY OF WASHINGTON (US) 2023-01-10 US disclosed
CN-111303150-B High-efficiency narrow-half-peak-width aggregation state luminescent material 苏州大学 2021-10-19 CN disclosed
CN-111303150-A High-efficiency narrow-half-peak-width aggregation state luminescent material 苏州大学 2020-06-19 CN disclosed
WO-2018021970-A1 CONJUGATED POLYVIOLOGEN DERIVATIVES AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2018-02-01 WO disclosed
CN-105593714-A Long optical film, circularly polarizing plate provided with long optical film, and organic electroluminescent display device KONICA MINOLTA INC 2016-05-18 CN disclosed
US-20160003995-A1 OPTICAL FILM, CIRCULARLY POLARIZING PLATE, AND ORGANIC ELECTROLUMINESCENT DISPLAY DEVICE Konica Minolta, Inc. (JP) 2016-01-07 US disclosed
CN-1777596-A Biaryltetrahydroisoquinoline piperidines as selective mch receptor antagonists for the treatment of obesity and related disorders SCHERING CORP (US) 2006-05-24 CN disclosed
EP-0797789-B1 NOVEL DIHYDRAZIDES AS DOT-PROMOTING AGENTS IN PHOTOGRAPHIC IMAGE SYSTEMS INT PAPER CO (US) 1998-11-25 EP disclosed
US-4698091-A 2-phenylpyrimidines, 2-naphthylpyrimidines and 2-heterocyclylpyrimidines as safeners for protecting cultivated plant against phytotoxic damage caused by herbicides CIBA-GEIGY CORPORATION (US) 1987-10-06 US disclosed
US-3932388-A STEROIDS, GLUCOCORTICOID ACITIVITY SCHERING CORPORATION (US) 1976-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11548875-B2 Inhibitor compounds for male contraception ALDH1A1, ALDH3A1, ALDH16A1 LMNA 1751/4885MAPT 4083/4885LTA4H 2814/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.