Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16804404 | 0.88 | METAP2 (0.44) | METAP2GAAALDH1A1LMNA | |
| SCHEMBL16804205 | 0.88 | HDAC6 (0.45) | METAP2 | |
| SCHEMBL16804456 | 0.86 | STAT6 (0.46) | GLO1STAT6 | |
| SCHEMBL16804452 | 0.85 | PDE1B (0.42) | GLO1METAP2GRM2GAAALDH1A1 | |
| SCHEMBL16794784 | 0.76 | HRH4 (0.46) | METAP2USP2STAT6ALDH1A1 | |
| SCHEMBL18109083 | 0.76 | HDAC6 (0.43) | — | |
| SCHEMBL16804373 | 0.75 | STAT6 (0.46) | METAP2GAASTAT6ALDH1A1CSF1R | |
| SCHEMBL16804195 | 0.75 | METAP2 (0.45) | METAP2GAASTAT6LMNA | |
| SCHEMBL16804317 | 0.74 | CKS1B (0.43) | METAP2 | |
| SCHEMBL16804277 | 0.74 | HDAC6 (0.52) | STAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015087151-A1 | NOVEL AZAINDOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE (HDAC) INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2015-06-18 | — | — | WO | disclosed |