Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 4/20 | 0.46 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16804277 | 0.88 | HDAC6 (0.52) | STAT6HDAC6PIK3CA | |
| SCHEMBL16804373 | 0.87 | STAT6 (0.46) | STAT6PIK3CAMAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL20525319 | 0.86 | STAT6 (0.42) | STAT6JAK2PIK3CAMAPK1PIK3CD | |
| SCHEMBL16804451 | 0.86 | GLO1 (0.41) | STAT6GLO1 | |
| SCHEMBL16804452 | 0.83 | PDE1B (0.42) | HDAC6MAPK1GLO1KMT2A | |
| SCHEMBL18852777 | 0.78 | SMN1; SMN2 (0.53) | STAT6SMN1; SMN2 | |
| SCHEMBL18126845 | 0.78 | SMN1; SMN2 (0.53) | HDAC6PIK3CAHDAC3HDAC2SMN1; SMN2 | |
| SCHEMBL16794784 | 0.78 | HRH4 (0.46) | STAT6MAPK1KMT2A | |
| SCHEMBL16804195 | 0.75 | METAP2 (0.45) | STAT6MAPK1HDAC3HDAC2 | |
| SCHEMBL18126841 | 0.75 | SMN1; SMN2 (0.51) | HDAC6PIK3CAHDAC3HDAC2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015087151-A1 | NOVEL AZAINDOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE (HDAC) INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2015-06-18 | — | — | WO | disclosed |